Research Article
Tumor Budding, uPA, and PAI-1 in Colorectal Cancer: Update of a Prospective Study
Table 4
Previous studies investigating the prognostic role of uPA and PAI-1 in colorectal cancer.
| References | Year | | Specimen | Protease | Method | Results |
| Mutoh et al. [6] | 2008 | 25 | Mice experimental | PAI-1 and PAI-1 inhibitors SK116 and 215 | ELISA, RT-PCR, polyp formation, tissue | PAI-1 Blockers suppress polyp formation | Minoo et al. [7] | 2009 | 975 | Colorectal | uPA, uPAR | IHC, microarray | uPA but not uPAR is independently prognostic | Yamada et al. [8] | 2010 | 100 | Colorectal | PAI-1 | ELISA, plasma | Predictive of postoperative recurrence | Kushlinskii et al. [9] | 2013 | 166 | Colorectal | uPA, PAI-1, tPA | ELISA, plasma | PAI-1 prognostic but only in univariate analysis | Hogan et al. [10] | 2013 | | Colon cancer and mesenchymal stem cells | PAI-1 | Cell cultures | PAI-1 is secreted by MSC | Kim et al. [11] | 2013 | 3136 | Colorectal | PAI-1 | ELISA, plasma | No independent association between PAI-1 and polyp-formation; univariable weakly significant | Iacoviello et al. [12] | 2013 | 850 | Colorectal | PAI-1 | ELISA, plasma | Risk factor for colorectal cancer | Sánchez-Tilló [13] | 2013 | | Colorectal | | Cell cultures | ZEB1 regulates uPA and PAI1 and promotes invasiveness | Chen et al. [14] | 2015 | 108 | Colorectal | PAI-1 | ELISA, plasma, and cell cultures | Silencing of PAI-1 suppresses CR cancer progression |
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ELISA, Enzyme-Linked Immunosorbent Assay; RT-PCR, reverse transcription polymerase chain reaction; IHC, immunohistochemistry; MSC, mesenchymal stem cells; CR, colorectal. Note: literature from 1993–2008 is given in [4].
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