Baseline Renal Function Predicts Hyponatremia in Liver Cirrhosis Patients Treated with Terlipressin for Variceal Bleeding
Table 2
Characteristics of the patients categorized according to changes in serum sodium concentration.
Δ sodium 5–10 mEq ()
Δ sodium 10–15 mEq ()
Δ sodium > 15 mEq ()
value
Ascites
32 (68)
19 (95)
15 (71)
0.460
Hepatic encephalopathy
7 (15)
7 (35)
4 (19)
0.462
Hemoglobin, g/dL
9.5 ± 1.9
9.7 ± 2.1
9.2 ± 2.3
0.766
Bilirubin, mg/dL
2.4 ± 2.1
2.9 ± 1.9
1.4 ± 0.7
0.024
Albumin, g/dL
3.0 ± 0.6
3.0 ± 0.5
3.1 ± 0.6
0.575
INR
1.6 ± 0.5
1.7 ± 0.6
1.5 ± 0.2
0.275
Creatinine, mg/dL
0.8 ± 0.4
0.9 ± 0.4
0.8 ± 0.3
0.632
Initial sodium, mEq/
137.3 ± 4.0
137.0 ± 4.5
140.0 ± 5.0
0.05
MELD score
14.0 ± 5.3
16.0 ± 5.9
12.2 ± 2.4
0.059
Child-Pugh score
8.3 ± 2.5
9.4 ± 2.1
7.5 ± 1.1
0.031
Blood transfusion (packed red cells)
3.3 ± 2.3
3.2 ± 2.3
3.1 ± 1.9
0.963
Cumulative terlipressin dose (mg)
18.0 ± 4.4
17.6 ± 3.6
18.0 ± 2.6
0.932
Amount of free water hydration (L)
4.3 ± 2.3
5.4 ± 2.6
5.0 ± 1.9
0.134
INR: international normalized ratio; MELD: Model for End-Stage Liver Disease; the data are expressed as the means ± the standard deviations (ranges) or numbers (%).
