Antifibrotic Effect of Lactulose on a Methotrexate-Induced Liver Injury Model
Table 2
Normal
MTX + saline
MTX + lactulose
Plasma TGF-beta (pg/ml)
5.8 ± 0.9
48.5 ± 4.2
26.1 ± 4.4#
Plasma MDA (nM)
41.09 ± 5.1
216.8 ± 12.6
105.9 ± 10.07##
Plasma TNF-alpha (pg/ml)
21.9 ± 3.1
88.5 ± 7.2
35.03 ± 6.4#
Plasma pentraxin 3 (ng/ml)
1.17 ± 0.12
3.1 ± 0.34
1.5 ± 0.71##
ALT (IU/l)
22.5 ± 3.08
74.6 ± 4.4
48.9 ± 7.01#
Liver MDA (nmol/g tissue)
22.4 ± 2.5
71.8 ± 6.18
55.21 ± 9.2#
, MTX + lactulose group compared with normal group. ##, MTX + lactulose group compared with MTX + saline group. #, MTX + lactulose group compared with MTX + saline group.
