Associations of Fatty Liver Disease with Hypertension, Diabetes, and Dyslipidemia: Comparison between Alcoholic and Nonalcoholic Steatohepatitis
Table 1
Baseline characteristics of the enrolled subjects.
Whole cohort ()
ASH ()
NASH ()
value
Age, years
55 (43, 64)
58 (48, 66)
54 (42, 64)
0.0028
Sex, male/female
440/313
145/27
295/286
<0.0001
BMI, kg/m2
26.5 (23.5, 29.9)
22.1 (19.7, 24.5)
27.7 (24.8, 30.6)
<0.0001
BMI, <25/≥25 kg/m2, <30/≥30 kg/m2
286/282/185
131/34/7
155/248/178
<0.0001
Systolic blood pressure, mmHg
127 (116, 139)
130 (118, 140)
126 (116, 138)
0.056
Diastolic blood pressure, mmHg
78 (70, 85)
78 (70, 86)
78 (70, 85)
0.693
AST, IU/L
54 (35, 88)
61 (35.5, 137)
53 (35, 79.5)
0.0014
ALT, IU/L
67 (41, 115)
44 (27.5, 82)
73 (47.5, 120)
<0.0001
GGT, IU/L
73.5 (43, 156)
232.5 (121, 517.5)
62 (38, 101)
<0.0001
Fasting blood glucose, mg/dL
110 (98, 133)
113 (95, 134)
109 (98, 133)
0.705
Hemoglobin A1c, %
6.1 (5.6, 6.9)
5.6 (5.0, 6.5)
6.2 (5.7, 7.1)
<0.0001
Total cholesterol, mg/dL
194 (167, 226)
170 (138, 224)
198 (175, 226)
<0.0001
LDL cholesterol, md/dL†
114 (90, 139)
95 (59, 124)
116 (94, 140)
0.0001
HDL cholesterol, mg/dL
48 (40, 58)
44 (31, 61)
49 (41, 58)
0.033
Triglycerides, mg/dL
134 (96, 206)
128 (89, 198)
135 (99, 207)
0.244
Stage of liver fibrosis, F1/F2/F3/F4
227/234/185/107
41/38/29/64
186/196/156/43
<0.0001
HT, n (%)
342 (45.4)
71 (41.3)
271 (46.6)
0.215
Without medication, n (%)
118 (34.5)
24 (33.8)
94 (34.7)
With medication, n (%)
224 (65.5)
47 (66.2)
177 (65.3)
DM, n (%)
349 (46.3)
47 (27.3)
302 (52.0)
<0.0001
Without medication, n (%)
185 (53.0)
35 (74.5)
150 (49.7)
With medication, n (%)
164 (47.0)
12 (25.5)
152 (50.3)
DL, n (%)
436 (57.9)
52 (30.2)
384 (66.1)
<0.0001
Without medication, n (%)
237 (54.4)
21 (40.4)
216 (56.2)
With medication, n (%)
199 (45.6)
31 (59.6)
168 (43.8)
HT + DM, n (%)
202 (26.8)
27 (15.7)
175 (30.1)
<0.0001
HT + DL, n (%)
218 (29.0)
24 (14.0)
194 (33.4)
<0.0001
DM + DL, n (%)
247 (32.8)
20 (11.6)
227 (39.1)
<0.0001
HT + DM + DL, n (%)
147 (19.5)
13 (7.6)
134 (23.1)
<0.0001
≥2 of the 3 diseases, n (%)
373 (49.5)
45 (26.2)
328 (56.5)
<0.0001
ASH: alcoholic steatohepatitis; NASH: nonalcoholic steatohepatitis; BMI: body mass index; AST: aspartate aminotransferase; ALT: alanine aminotransferase; GGT: γ-glutamyl transpeptidase; LDL: low-density lipoprotein; HDL: high-density lipoprotein; HT: hypertension; DM: diabetes mellitus; DL: dyslipidemia. ASH versus NASH. Chi-square test for categorical variables, Mann–Whitney U test for continuous variables. †The Friedewald equation was used. Data excluded 7 subjects with ASH and 12 with NASH whose serum triglyceride levels were ≥400 mg/dL.
