Review Article
Efficacy and Safety of Argon Plasma Coagulation for Hemorrhagic Chronic Radiation Proctopathy: A Systematic Review
Table 2
Study characteristics of selected studies on the levels of hemoglobin and rectal bleeding before and after APC administration.
| | Author | Year | Type of study | Proctitis | Total number of bleeding | Number of rebleeding | Rate of hemostasis (%) | Mean level of hemoglobin before APC (g/dL) ± SD | Mean level of hemoglobin after APC (g/dL) ± SD |
| | Alfadhli | 2008 | Prospective | Prospective | 14 | 3 | 78.6 | na | na | | Álvaro-Villegas | 2011 | Prospective | Chronic radiation proctitis | 14 | 2 | 85.7 | 9.9 ± 2.3 | 11.3 ± 2 | | Ben | 2004 | Prospective | Hemorrhagic radiation proctitis | 27 | 2 | 92.6 | na | na | | Canard | 2003 | Prospective | Radiation proctitis | 28 | 2 | 92.9 | na | na | | Chruscielewska | 2013 | Prospective | Chronic radiation proctitis | 62 | 3 | 95.2 | 13.07 ± 1.73 | 13.96 ± 1.44 | | Chutkan | 1997 | Prospective | Proctitis | 12 | 1 | 91.7 | na | na | | Dees | 2006 | Prospective | Chronic radiation proctitis | 48 | 1 | 97.9 | na | na | | Fantin | 1999 | Retrospective | Proctitis | 7 | 0 | 100.0 | na | na | | de la Serna Higuera | 2004 | Retrospective | Hemorrhagic radiation proctopathy | 10 | 1 | 90.0 | na | na | | Hortelano | 2013 | Prospective | Chronic radiation proctitis | 30 | 7 | 76.7 | 9.6 (5.1–14.1) | 11.65 (10.2–14.6) | | Kaassis | 2000 | Retrospective | Proctitis | 16 | 1 | 93.8 | na | na | | Karamanolis | 2009 | Prospective | Radiation proctitis | 56 | 6 | 89.3 | na | na | | Latorre | 2008 | Prospective | Chronic radiation proctopathy | 38 | 5 | 86.8 | 11.3 ± 3.05 | 14.014 ± 1.29 | | Lenz | 2011 | Prospective | Chronic radiation coloproctopathy | 15 | 1 | 93.3 | 11.7 ± 2.7 | 13.0 ± 0.9 | | Lpoez | 2010 | Retrospective | Radiation proctopathy | 19 | 1 | 94.7 | 11.8 (7.3–16.5) | 12.9 (7.5–16.5) | | Onoyama | 2011 | Prospective | Chronic hemorrhagic radiation proctitis | 24 | 0 | 100.0 | 10 ± 2.2 | 12.3 ± 1.5 | | Rolachon A | 2000 | Prospective | Proctitis and proctosigmoiditis | 12 | 1 | 91.7 | 7.9 ± 2.1 | 11 ± 1.4 | | Rotondano | 2003 | Prospective | Chronic radiation proctopathy | 24 | 2 | 91.7 | 9.2 ± 2.4 | 13.6 ± 1.1 | | Sait Dag | 2013 | Retrospective | Radiation proctitis | 21 | 3 | 85.7 | na | na | | Samy | 2012 | Prospective | Chronic proctitis | 23 | 6 | 73.9 | na | na | | Sarah | 2001 | Prospective | Proctitis | 11 | 0 | 100.0 | 7.7 ± 2.8 | 11.5 ± 2.6 | | Sato | 2011 | Prospective | Hemorrhagic radiation proctopathy | 65 | 4 | 93.8 | 11.1 (5.8–13.3) | 13.7 (12–15.2) | | Sebastian | 2004 | Prospective | Radiation proctopathy | 25 | 4 | 84.0 | 10.05 ± 2.21 | 12.44 ± 1.09 | | Silva | 1999 | Prospective | Proctosigmoiditis | 28 | 1 | 96.4 | na | na | | Smith | 2001 | Prospective | Proctitis | 7 | 2 | 71.4 | na | na | | Swan | 2010 | Prospective | Chronic radiation proctitis | 49 | 1 | 98.0 | na | na | | Takemoto | 2012 | Prospective | Hemorrhagic radiation proctopathy | 12 | 2 | 83.3 | na | na | | Tam | 2000 | Retrospective | Proctitis | 15 | 0 | 100.0 | 10.8 ± 2.57 | 13.3 ± 1.84 | | Tjandra | 2001 | Prospective | Hemorrhagic proctitis | 12 | 6 | 50.0 | 11.18 ± 0.82 | 12.28 ± 0.55 | | Venkatesh | 2002 | Prospective | Radiation proctitis | 40 | 1 | 97.5 | na | na | | Villavicencio | 2002 | Prospective | Hemorrhagic radiation proctopathy | 21 | 0 | 100.0 | na | na | | Yeoh | 2013 | Prospective | Chronic radiation proctitis | 17 | 1 | 94.1 | 14 (97–159) | 13.6 (10.6–17.4) | | Zinicola | 2003 | Retrospective | Radiation proctitis | 12 | 2 | 83.3 | na | na |
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