Gastroenterology Research and Practice / 2018 / Article / Tab 2 / Review Article
Cross-Talk between Gut Microbiota and Heart via the Routes of Metabolite and Immunity Table 2 Summary of the human randomized controlled trials analyzing the effect of probiotic supplementation on CVD.
Authors Aim Population Main findings Duration Karlsson et al. [56 ] To clarify the effect of L. plantarum (DSM 9843) on intestinal microbiota in patients with cardiovascular disease 16 males with atherosclerotic plaque Increased bacterial diversity and decreased concentration of isovaleric acid and valeric acid 4 weeks Matsumoto et al. [57 ] To investigate the effect of probiotic Bifidobacterium animalis subsp. lactis LKM512 on colonic TMA and atherosclerosis-related makers in healthy subjects 27 healthy adults Reduced fecal TMA concentration and BMI 12 weeks Tripolt et al. [59 ] To investigate the impact of Lactobacillus casei Shirota (LcS) on the formation of TMAO in subjects with metabolic syndrome 30 subjects with metabolic syndrome Not affecting levels of TMAO 12 weeks Boutagy et al. [60 ] To investigate whether multistrain probiotic VSL#3 would attenuate the increase in fasting plasma concentrations of TMAO following a high-fat diet Nonobese males Not affecting levels of TMAO 2 weeks