Is Combination Antiviral Therapy Mandatory for Maintenance Therapy in Fully Suppressed Multidrug-Resistant Hepatitis B Patients?

Figure 4

Extended Kaplan-Meier curves of cumulative incidence of hepatocellular carcinoma (HCC) development, stratified by time-varying TDF monotherapy status. The index date was set as the date of complete virologic suppression. Hazard ratio (HR), 95% confidence intervals (CI), and values were calculated by the time-varying Cox proportional hazard model with time-varying covariate. CI: confidence interval; HCC: hepatocellular carcinoma; HR: hazard ratio; TDF: tenofovir disoproxil fumarate.