SMAD4 Protein Expression Is Downregulated in Ileal Epithelial Cells from Patients with Crohn’s Disease with Significant Inverse Correlation to Disease Activity

<div>Immunohistochemical staining of SMAD4 on ileal biopsies. The luminal SMAD4 protein expression (brown color) was decreased in CD patients with active disease (aCD) (a, b) compared to CD patients in remission (rCD) (c, d) and healthy controls (e, f). Original magnification ×20 (a, c, and e) and ×40 (b, d, and f). Luminal (g) and basal (h) SMAD4 was significantly downregulated in CD patients compared to controls. Median and IQR are shown.</div>

Gastroenterology Research and Practice

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Figure 1

Figure 1: SMAD4 Protein Expression Is Downregulated in Ileal Epithelial Cells from Patients with Crohn’s Disease with Significant Inverse Correlation to Disease Activity 

Figure 1 | SMAD4 Protein Expression Is Downregulated in Ileal Epithelial Cells from Patients with Crohn’s Disease with Significant Inverse Correlation to Disease Activity 