SMAD4 Protein Expression Is Downregulated in Ileal Epithelial Cells from Patients with Crohn’s Disease with Significant Inverse Correlation to Disease Activity

<div>Immunohistochemical staining of SMAD7 on ileal biopsies. The lamina propria mononuclear cell (LPMC) SMAD7 protein expression (brown color) was similar in CD patients with active disease (aCD) (a, b) compared to controls (e, f). SMAD7 was downregulated in CD patients in remission (rCD) (c, d). Original magnification ×20 (a, c, and e) and ×40 (b, d, and f). SMAD downregulation in CD patients in remission was significant compared to controls and active CD (g). Median and IQR are shown.</div>

Gastroenterology Research and Practice

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Figure 2: SMAD4 Protein Expression Is Downregulated in Ileal Epithelial Cells from Patients with Crohn’s Disease with Significant Inverse Correlation to Disease Activity 

Figure 2 | SMAD4 Protein Expression Is Downregulated in Ileal Epithelial Cells from Patients with Crohn’s Disease with Significant Inverse Correlation to Disease Activity 