Celiac disease is globally emerging and it is becoming prevalent even in regions where it was once thought to be rare. Increase in the awareness, availability of reliable serological tests, and relaxation in the diagnostic criteria led to a marked increase in the detection of celiac disease. There has been a remarkable change in the understanding of immunopathogenesis and genetics of celiac disease. The kind of interaction between immune system and genes that occurs in celiac disease is being explored. A few genome-wide association studies have pointed out a sharing of a few genetic loci amongst patients with celiac disease and other autoimmune diseases such as type 1 diabetes and rheumatoid arthritis. Animal models for celiac disease are being developed. New diagnostic markers and markers for followup of celiac disease are now an area of great interest. Other than gluten-free diet, which is the standard of care, many new therapeutic targets are being investigated and in fact few of them look promising.

In this special issue, we particularly take an interest in manuscripts that deal with any aspect of celiac disease. Potential topics include, but are not limited to:

• Epidemiology of celiac disease
• Immunopathogenesis of celiac disease
• Antigen entry through tight junctions
• Genetics studies
• Gut metagenome
• Variation in the presentation of celiac disease
• Newer diagnostic tests
• Emerging therapies

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/grp/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable: