Evolution of Interferon-Based Therapy for Chronic Hepatitis C

Table 2

Factors associated with response to interferon-based therapy for hepatitis C.

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Baseline

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 Virological factors

   Hepatitis C virus genotype

   Hepatitis C viral loads

   Quasispecies

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 Host factors

   Bridging fibrosis/cirrhosis

   Gender

   Age

   Ethnicity

   Insulin resistance

   Obesity

   Hepatic steatosis

   Host genetics: genetic variation in IL28B

   Coinfection with HIV

   Nonresponse to previous interferon-based therapy

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On-treatment

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   Rapid virological response (RVR) at week 4

   Early virological response (EVR) at week 12  

     Complete EVR (cEVR) versus Partial EVR (pEVR)

   Medical adherence

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