(a) Classical Cryoglobulinemia-related small vessel vasculitis of lower extremities characterized by erythematosus palpable maculopapular rash in a HCV positive patient (b) Cryoglobulin precipitates in serum. the left tube is at room temperature; the right tube has been in the 4°C incubator, and the cryoglobulin has precipitated out and settled to the bottom of the tube, (c) Serum protein electrophoresis (ELP) of the cryoprecipitate reveals both a homogeneous band and a smear pattern in the gamma zone (indicating a cryoglobulin composed of monoclonal and polyclonal gamma globulins. G: gamma, A: alpha, M: Mu, K: kappa, and L: lambda immunoglobulin bands.