Hepatitis B and Hepatitis C Infection Biomarkers and TP53 Mutations in Hepatocellular Carcinomas from Colombia

Table 1

Clinicopathological data of HCC cases diagnosed at four health reference institutions during the period 2000–2007 in Colombia.

	Frequency (%) 𝑛=49
Mean age	63.5 years
Age range	25–88 years
Gender female/male	43.2%/56.8%
Edmondson and Steiner's grade
G1	4.9%
G2	39%
G3	56.1%
Histological type
Trabecular	56.5%
Solid	21.7%
Mixte	13%
Glandular	4.4%
Pseudo-glandular	4.4%
Biomarkers
HBV	58.1% (25/43)
HCV	37% (10/27)
Coinfection	19.2% (5/26)
AFB1-DNA adducts	0% (0/31)
TP53 gene
Exon 7 (249^ser mutation)	10.5% (4/38)
Exon 5 (G12457T mutation)	2.9% (1/34)
Exon 8 (G13804A mutation)	2.9% (1/34)