Hepatitis C Virus: A Critical Appraisal of New Approaches to Therapy

Table 6

RGT Guidelines: Treatment-Naïve Patients.

When to Evaluate HCV-RNA Results
	Boceprevir [6]
At Treatment Week 8 and Week 12	At Treatment Week 24	Recommendation
Undetectable	Undetectable	Complete three-medicine regimen at TW28
Detectable	Undetectable	(1) Continue all three medicines and finish through TW36; and then; (2) Administer peginterferon alfa and ribavirin and finish through TW48
	Telaprevir [5]
At Treatment Week 4 and Week 12	Recommendation
Undetectable	Receive an additional 12 weeks of PEG-IFN/RBV alone for total treatment duration of 24 weeks
Detectable	Receive an additional 36 weeks of PEG-IFN/RBV alone for a total treatment duration of 48 weeks

TW: treatment week.