Hepatitis C Virus: A Critical Appraisal of New Approaches to Therapy
Table 7
Boceprevir Dosing in Treatment-Experienced Patients [6].
Boceprevir
HCV Genotype 1 Dosing
Previous Partial Responders or Relapsers Without Cirrhosis
PEG-IFN/RBV for 4 weeks, then BOC 800 mg (four 200 mg capsules) orally 3 times daily (every 7–9 hours) with food [meal/light snack] to PEG-IFN/RBV regimen after 4 weeks of treatment—then RGT
Previous Partial Responders or Relapsers With Compensated Cirrhosis
OR
4 weeks PEG-IFN/RBV followed by 44 weeks BOC 800 mg 3 times daily in combination with PEG-IFN/RBV
<2-log10 HCV-RNA decline by treatment week 12 during prior therapy with PEG-IFN/RBV
Response-Guided Therapy
Assessment (HCV-RNA Results)
Recommendation
At Treatment Week 8
At Treatment Week 24
Previous partial responders or relapsers
Undetectable
Undetectable
Complete 3-medicine regimen at TW36
Detectable
Undetectable
(1) Continue all 3 medicines and finish through TW36 and then:
(2) Administer PEG-IFN/RBV and finish through TW48
