Boceprevir (BOC)* Treatment-naïve without cirrhosis
PEG-IFN/RBV for 4 weeks, then BOC 800 mg (four 200 mg capsules) orally 3 times daily (every 7–9 hours) with food [meal/light snack] to PEG-IFN/RBV regimen after 4 weeks of treatment—then RGT
Boceprevir* Treatment-naïve patients with cirrhosis
4 weeks PEG-IFN/RBV followed by 44 weeks BOC 800 mg (four 200 mg capsules) 3 times daily (every 7–9 hours) in combination with PEG-IFN/RBV
Telaprevir (TVR)**
TVR 750 mg (two 375 mg tablets) taken orally 3 times a day (7–9 hours apart) with food in combination with PEG-IFN/RBV for 12 weeks
*No dosage adjustment required for patients with any degree of renal impairment or for mild, moderate, or severe hepatic impairment. **Not recommended for patients with moderate or severe hepatic impairment (Child-Pugh B or C, score ≥ to 7) or patients with decompensated liver disease. RGT: response-guided therapy.
