Minocycline Decreases Liver Injury after Hemorrhagic Shock and Resuscitation in Mice
Figure 1
Minocycline decreases ALT release after hemorrhage and resuscitation. Mice were resuscitated with shed blood and then half the volume of lactated Ringer’s solution containing tetracycline or minocycline (10 mg/kg body weight) or vehicle, as described in materials and methods. Serum ALT was assessed 6 h after resuscitation. Group sizes were sham, 4; vehicle, 7; minocycline, 7; tetracycline, 7. * versus vehicle and tetracycline.
