Minocycline Decreases Liver Injury after Hemorrhagic Shock and Resuscitation in Mice
Figure 5
Minocycline decreases oxidative stress after hemorrhage and resuscitation. H/R was performed, as described in Figure 1, and immunohistochemical staining was performed for 4-HNE adducts at 6 h after sham operation (a) or resuscitation with vehicle, minocycline, or tetracycline (b–d). In (e), HNE staining as percent area in liver sections was averaged from 5 livers per group. HNE in sham-operated livers was virtually zero and not plotted. Individual group size was 5. Bar is 50 μm. * versus vehicle.
