Small-for-Size Liver Transplantation Increases Pulmonary Injury in Rats: Prevention by NIM811

Figure 5

NIM811 protects against apoptosis in the lung after transplantation of small-for-size liver grafts. Lungs were harvested 38 h after transplantation. Representative images of pulmonary slides (𝑛=4 per group) after TUNEL staining are shown in (a)–(d). TUNEL-positive cells were counted in 10 random fields per slide using a 20x objective lens (e). Sham: lungs from sham-operated rats; 100%: lungs from FSG recipients; 50%: lungs from HSG recipient; 25%: lungs from QSG recipients; 25% + NIM: lungs from recipients of QSG treated with NIM811. Values are means ± S.E.M. Group sizes were 4 per group. (a) 𝑃<0.05 versus sham operation; (b) 𝑃<0.05 versus FSG (100%); (c) 𝑃<0.05 versus HSG (50%); (d) 𝑃<0.05 versus QSG (25%).

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