Small-for-Size Liver Transplantation Increases Pulmonary Injury in Rats: Prevention by NIM811

Figure 6

Hepatic toxic cytokine formation and pulmonary expression of adhesion molecules increased after transplantation of small-for-size liver grafts: Reversal by NIM811. Liver grafts and lungs were harvested at 38 h after transplantation. TNFα (a) and IL-1𝛽 (b) mRNAs were detected by real-time PCR. Values are means ± S.E.M. Group sizes were 4 per group. (a) 𝑃<0.05 versus sham operation; (b) 𝑃<0.05 versus FSG (100%); (c) 𝑃<0.05 versus HSG (50%); (d) 𝑃<0.05 versus QSG (25%). In (c)–(g) pulmonary ICAM-1 expression was detected immunohistochemically, and representative images are shown (𝑛=4 per group): (c) lung from a sham-operated rat; (d) lung from a FSG recipient (100%); (e) lung from HSG graft recipient (50%); (f) lung from QSG recipient (25%); (g) lung from a recipient of QSG pretreated with NIM811.