ICAM-1 Upregulation in Ethanol-Induced Fatty Murine Livers Promotes Injury and Sinusoidal Leukocyte Adherence after Transplantation
Figure 6
Decreased lipid peroxidation occurs in ICAM-1 deficient liver grafts. At 2 and 8 h after transplantation or sham operation, immunohistochemical staining was performed for 4-hydroxynonenal-modified proteins (4-HNE, brown), as described in Section 2. Panels are sham-operated wild type (WT) livers (a), sham-operated ICAM-1 deficient (KO) livers (b), WT liver grafts at 2 h after reperfusion (c), KO liver grafts at 2 h after reperfusion (d), WT liver grafts at 8 h after reperfusion (e), and KO liver grafts at 8 h after reperfusion (f). Brown HNE immunoreactivity was present in WT grafts after 2 and 8 h ((c) and (e)), which was markedly decreased in KO livers ((d) and (f)). Size of groups was 4. Bar is 50 μm.
