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HPB Surgery
Volume 2012 (2012), Article ID 891787, 14 pages
doi:10.1155/2012/891787
Review Article
“Incidentaloma” of the Liver: Management of a Diagnostic and Therapeutic Dilemma
1Department of Visceral, Thoracic und Vascular Surgery, Clinic of Dachau, 85221 Dachau, Germany
2Department of Radiology, Clinic of Dachau, Krankenhausstrare 15, 85221 Dachau, Germany
Received 8 February 2012; Revised 20 April 2012; Accepted 5 May 2012
Academic Editor: Alfred Königsrainer
Copyright © 2012 Denis Ehrl et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- N. Assy, G. Nasser, A. Djibre, Z. Beniashvii, S. Elias, and J. Zidan, “Characteristics of common solid liver lesions and recommendations for diagnostic workup,” World Journal of Gastroenterology, vol. 15, no. 26, pp. 3217–3227, 2009. View at Publisher · View at Google Scholar · View at Scopus
- S. Delorme, “Radiologische diagnostik der leber,” Radiologe, vol. 40, no. 10, pp. 904–915, 2000. View at Publisher · View at Google Scholar · View at Scopus
- M. Galanski, S. Jördens, and J. Weidemann, “Diagnosis and differential diagnosis of benign liver tumors and tumor-like lesions,” Chirurg, vol. 79, no. 8, pp. 707–721, 2008. View at Publisher · View at Google Scholar · View at Scopus
- M. Loss, C. Zülke, A. Obed, O. Stöltzing, and H. J. Schlitt, “Surgical therapy of benign liver tumors,” Chirurg, vol. 79, no. 8, pp. 722–728, 2008. View at Publisher · View at Google Scholar · View at Scopus
- T. Skalický, V. Třeška, A. Sutnar et al., “Surgical treatment of benign liver tumours—indications and results,” Zentralblatt fur Chirurgie, vol. 134, no. 2, pp. 141–144, 2009. View at Publisher · View at Google Scholar · View at Scopus
- D. Strobel and T. Bernatik, “Diagnostik bei fokalen Leberläsionen-Stellenwert der Kontrastmittelsonografie,” Deutsches Ärzteblatt, vol. 103, pp. 789–793, 2006.
- B. S. Kuszyk, D. A. Bluemke, B. A. Urban et al., “Portal-phase contrast-enhanced helical CT for the detection of malignant hepatic tumors: sensitivity based on comparison with intraoperative and pathologic findings,” American Journal of Roentgenology, vol. 166, no. 1, pp. 91–95, 1996. View at Scopus
- L. H. Schwartz, E. J. Gandras, S. M. Colangelo, M. C. Ercolani, and D. M. Panicek, “Prevalence and importance of small hepatic lesions found at CT in patients with cancer,” Radiology, vol. 210, no. 1, pp. 71–74, 1999. View at Scopus
- P. J. Karhunen, A. Penttila, and K. Liesto, “Benign bile duct tumours, non-parasitic liver cysts and liver damage in males,” Journal of Hepatology, vol. 2, no. 1, pp. 89–99, 1986. View at Scopus
- K. Hoffmann and P. Schemmer, “Benigne solide Tumoren der Leber,” Allgemein- und Viszeralchirurgie Up2date, vol. 5, pp. 135–146, 2011.
- C. Zülke, M. Loss, I. Iesalnieks et al., “Benign liver lesions: indication for surgery and postoperative results,” Viszeralchirurgie, vol. 39, no. 2, pp. 86–97, 2004. View at Publisher · View at Google Scholar · View at Scopus
- J. Belghiti, D. Pateron, Y. Panis et al., “Resection of presumed benign liver tumours,” British Journal of Surgery, vol. 80, no. 3, pp. 380–383, 1993. View at Scopus
- A. Blachar, M. P. Federle, J. V. Ferris et al., “Radiologists' performance in the diagnosis of liver tumors with central scars by using specific CT criteria,” Radiology, vol. 223, no. 2, pp. 532–539, 2002. View at Scopus
- M. P. Federle and G. Brancatelli, “Imaging of benign hepatic masses,” Seminars in Liver Disease, vol. 21, no. 2, pp. 237–249, 2001. View at Publisher · View at Google Scholar · View at Scopus
- A. M. Xu, H. Y. Cheng, D. Chen, Y. C. Jia, and M. C. Wu, “Plane and weighted tri-phase helical CT findings in the diagnosis of liver focal nodular hyperplasia,” Hepatobiliary and Pancreatic Diseases International, vol. 1, no. 2, pp. 219–223, 2002. View at Scopus
- N. Corigliano, P. Mercantini, P. M. Amodio et al., “Hemoperitoneum from a spontaneous rupture of a giant hemangioma of the liver: report of a case,” Surgery Today, vol. 33, no. 6, pp. 459–463, 2003. View at Publisher · View at Google Scholar · View at Scopus
- T. Terkivatan, J. H. W. de Wilt, R. A. de Man, R. R. van Rijn, H. W. Tilanus, and J. N. M. Ijzermans, “Treatment of ruptured hepatocellular adenoma,” British Journal of Surgery, vol. 88, no. 2, pp. 207–209, 2001. View at Publisher · View at Google Scholar · View at Scopus
- H. J. Gassel, I. Klein, U. Steger, M. Simon, and A. Thiede, “Cavernous liver hemangioma: rational diagnostics and therapeutic approach,” Viszeralchirurgie, vol. 40, no. 1, pp. 37–44, 2005. View at Publisher · View at Google Scholar · View at Scopus
- M. Donati, G. A. Stavrou, A. Donati, and K. J. Oldhafer, “The risk of spontaneous rupture of liver hemangiomas: a critical review of the literature,” Journal of Hepato-Biliary-Pancreatic Surgery. In press.
- J. H. Sewell and K. Weiss, “Spontaneous rupture of hemangioma of the liver. A review of the literature and presentation of illustrative case,” Archives of Surgery, vol. 83, pp. 729–733, 1961. View at Scopus
- S. I. Schwartz and W. C. Husser, “Cavernous hemangioma of the liver. A single institution report of 16 resections,” Annals of Surgery, vol. 205, no. 5, pp. 456–465, 1987. View at Scopus
- O. Farges, S. Daradkeh, and H. Bismuth, “Cavernous hemangiomas of the liver: are there any indications for resection?” World Journal of Surgery, vol. 19, no. 1, pp. 19–24, 1995. View at Publisher · View at Google Scholar · View at Scopus
- D. Erdogan, O. R. C. Busch, O. M. van Delden, F. J. W. Ten Kate, D. J. Gouma, and T. M. van Gulik, “Management of spontaneous haemorrhage and rupture of hepatocellular adenomas. A single centre experience,” Liver International, vol. 26, no. 4, pp. 433–438, 2006. View at Publisher · View at Google Scholar · View at Scopus
- J. H. B. M. Stoot, R. J. S. Coelen, M. C. de Jong, and C. H. Dejong, “Malignant transformation of hepatocellular adenomas into hepatocellular carcinomas: a systematic review including more than 1600 adenoma cases,” HPB, vol. 12, no. 8, pp. 509–522, 2010. View at Scopus
- P. Flemming, U. Lehmann, D. Steinemann, H. Kreipe, and L. Wilkens, “Leberzelladenom. Entartungspotenzial und abgrenzung vom HCC,” Pathologe, vol. 27, no. 4, pp. 238–243, 2006. View at Scopus
- L. Chiche, T. Dao, E. Salamé et al., “Liver adenomatosis: reappraisal, diagnosis, and surgical managemen: 8 new cases and review of the literature,” Annals of Surgery, vol. 231, no. 1, pp. 74–81, 2000. View at Publisher · View at Google Scholar · View at Scopus
- L. Grazioli, M. P. Federle, T. Ichikawa, E. Balzano, M. Nalesnik, and J. Madariaga, “Liver adenomatosis: clinical, histopathologic, and imaging findings in 15 patients,” Radiology, vol. 216, no. 2, pp. 395–402, 2000. View at Scopus
- L. Grazioli, M. P. Bondioni, H. Haradome et al., “Hepatocellular adenoma and focal nodular hyperplasia: value of gadoxetic acid-enhanced MR imaging in differential diagnosis,” Radiology, vol. 262, no. 2, pp. 520–529, 2012. View at Publisher · View at Google Scholar · View at Scopus
- J. Neuberger, B. Portmann, H. B. Nunnerley, M. Davis, J. W. Laws, and R. Williams, “Oral-contraceptive-associated liver tumours: occurrence of malignancy and difficulties in diagnosis,” The Lancet, vol. 1, no. 8163, pp. 273–276, 1980. View at Scopus
- L. C. Tao, “Oral contraceptive-associated liver cell adenoma and hepatocellular carcinoma: cytomorphology and mechanism of malignant transformation,” Cancer, vol. 68, no. 2, pp. 341–347, 1991. View at Publisher · View at Google Scholar · View at Scopus
- B. Y. Choi and M. H. Nguyen, “The diagnosis and management of benign hepatic tumors,” Journal of Clinical Gastroenterology, vol. 39, no. 5, pp. 401–412, 2005. View at Publisher · View at Google Scholar · View at Scopus
- C. Zülke and H. J. Schlitt, “Incidentalomas of the liver and gallbladder : evaluation and therapeutic procedure,” Chirurg, vol. 78, no. 8, pp. 698–712, 2007. View at Publisher · View at Google Scholar · View at Scopus
- P. J. Mergo, J. D. Engelken, T. Helmberger, and P. R. Ros, “MRI in focal liver disease: a comparison of small and ultrasmall superparamagnetic iron oxide as hepatic contrast agents,” Journal of Magnetic Resonance Imaging, vol. 8, no. 5, pp. 1073–1078, 1998. View at Publisher · View at Google Scholar · View at Scopus
- A. J. Ruppert-Kohlmayr, M. M. Uggowitzer, C. Kugler, D. Zebedin, G. Schaffler, and G. S. Ruppert, “Focal nodular hyperplasia and hepatocellular adenoma of the liver: differentiation with multiphasic helical CT,” American Journal of Roentgenology, vol. 176, no. 6, pp. 1493–1498, 2001. View at Scopus
- T. Isozaki, K. Numata, T. Kiba et al., “Differential diagnosis of hepatic tumors by using contrast enhancement patterns at US,” Radiology, vol. 229, no. 3, pp. 798–805, 2003. View at Publisher · View at Google Scholar · View at Scopus
- D. Strobel, S. Raeker, P. Martus, E. G. Hahn, and D. Becker, “Phase inversion harmonic imaging versus contrast-enhanced power Doppler sonography for the characterization of local liver lesions,” International Journal of Colorectal Disease, vol. 18, no. 1, pp. 63–72, 2003. View at Publisher · View at Google Scholar · View at Scopus
- D. G. D. Wight, Atlas of Liver Pathology, Kluwer Academic Publishers, Dordrecht, The Netherlands, 2nd edition, 1993.
- K. F. Gratz and A. Weimann, “Diagnosis of liver tumors—when is scintigraphy of value?” Zentralbl Chir, vol. 123, pp. 111–118, 1998.
- J. Grimm, S. Müller-Hülsbeck, J. Blume, J. Biederer, and M. Heller, “Comparison of biphasic spiral CT and MnDPDP-enhanced MRI in the detection and characterization of liver lesions,” Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr, vol. 173, pp. 266–272, 2001.
- P. Herman, V. Pugliese, M. A. C. Machado et al., “Hepatic adenoma and focal nodular hyperplasia: differential diagnosis and treatment,” World Journal of Surgery, vol. 24, no. 3, pp. 372–376, 2000. View at Publisher · View at Google Scholar · View at Scopus
- S. Shimizu, T. Takayama, T. Kosuge et al., “Benign tumors of the liver resected because of a diagnosis of malignancy,” Surgery Gynecology and Obstetrics, vol. 174, no. 5, pp. 403–407, 1992. View at Scopus
- A. Weimann, B. Ringe, J. Klempnauer et al., “Benign liver tumors: differential diagnosis and indications for surgery,” World Journal of Surgery, vol. 21, no. 9, pp. 983–991, 1997. View at Publisher · View at Google Scholar · View at Scopus
- G. T. Huang, J. C. Sheu, P. M. Yang, H. S. Lee, T. H. Wang, and D. S. Chen, “Ultrasound-guided cutting biopsy for the diagnosis of hepatocellular carcinoma—a study based on 420 patients,” Journal of Hepatology, vol. 25, no. 3, pp. 334–338, 1996. View at Publisher · View at Google Scholar · View at Scopus
- E. H. Smith, “Complications of percutaneous abdominal fine-needle biopsy: review,” Radiology, vol. 178, no. 1, pp. 253–258, 1991. View at Scopus
- N. Corigliano, P. Mercantini, P. M. Amodio et al., “Hemoperitoneum from a spontaneous rupture of a giant hemangioma of the liver: report of a case,” Surgery Today, vol. 33, no. 6, pp. 459–463, 2003. View at Publisher · View at Google Scholar · View at Scopus
- T. Terkivatan, J. H. de Wilt, R. A. de Man et al., “Indications and long-term outcome of treatment for benign hepatic tumors: a critical appraisal,” Archives of Surgery, vol. 136, no. 9, pp. 1033–1038, 2001. View at Scopus
- C. K. Charny, W. R. Jarnagin, L. H. Schwartz et al., “Management of 155 patients with benign liver tumours,” British Journal of Surgery, vol. 88, no. 6, pp. 808–813, 2001. View at Publisher · View at Google Scholar · View at Scopus
- V. D'Halluin, V. Vilgrain, G. Pelletier et al., “Natural history of focal nodular hyperplasia. A retrospective study of 44 cases,” Gastroenterologie Clinique et Biologique, vol. 25, no. 11, pp. 1008–1010, 2001. View at Scopus
- R. Gedaly, J. J. Pomposelli, E. A. Pomfret, W. D. Lewis, and R. L. Jenkins, “Cavernous hemangioma of the liver: anatomic resection versus enucleation,” Archives of Surgery, vol. 134, no. 4, pp. 407–411, 1999. View at Publisher · View at Google Scholar · View at Scopus
- B. Descottes, D. Glineur, F. Lachachi et al., “Laparoscopic liver resection of benign liver tumors: results of a multicenter European experience,” Surgical Endoscopy and Other Interventional Techniques, vol. 17, no. 1, pp. 23–30, 2003. View at Publisher · View at Google Scholar · View at Scopus
- H. G. Rau, E. Buttler, G. Meyer, H. M. Schardey, and F. W. Schildberg, “Laparoscopic liver resection compared with conventional partial hepatectomy—a prospective analysis,” Hepatogastroenterology, vol. 45, no. 24, pp. 2333–2338, 1998. View at Scopus
- H. G. Rau, A. Zimmermann, C. Wardemann, and F. W. Schildberg, “Standards of surgical techniques in liver metastases,” Chirurgische Gastroenterologie Interdisziplinar, vol. 19, no. 4, pp. 333–339, 2003. View at Publisher · View at Google Scholar · View at Scopus
- A. Petri, J. Höhn, A. Wolfárd et al., “Surgery of benign liver tumors: indications for treatment. Personal experience and review of the literature,” Magyar Onkologia, vol. 47, no. 4, pp. 391–395, 2003. View at Scopus
- T. Terkivatan, J. H. de Wilt, R. A. de Man et al., “Indications and long-term outcome of treatment for benign hepatic tumors: a critical appraisal,” Archives of Surgery, vol. 136, no. 9, pp. 1033–1038, 2001. View at Scopus
- S. C. Gordon, K. J. Reddy, and A. S. Livingstone, “Resolution of a contraceptive-steroid-induced hepatic adenoma with subsequent evolution into hepatocellular carcinoma,” Annals of Internal Medicine, vol. 105, no. 4, pp. 547–549, 1986. View at Scopus
- H. Tesluk and J. Lawrie, “Hepatocellular adenoma. Its transformation to carcinoma in a user of oral contraceptives,” Archives of Pathology and Laboratory Medicine, vol. 105, no. 6, pp. 296–299, 1981. View at Scopus
- N. Ren, L. X. Qin, Z. Y. Tang, Z. Q. Wu, and J. Fan, “Diagnosis and treatment of hepatic angiomyolipoma in 26 cases,” World Journal of Gastroenterology, vol. 9, no. 8, pp. 1856–1858, 2003. View at Scopus
- C. N. Yeh, M. F. Chen, C. F. Hung, T. C. Chen, and T. C. Chao, “Angiomyolipoma of the liver,” Journal of Surgical Oncology, vol. 77, no. 3, pp. 195–200, 2001.
- O. Katsuhisa, O. Kazuo, Y. Kadokawa et al., “Comparison of the grade evaluated by “Liver damage” of Liver Cancer Study Group of Japan and Child-Pugh classification in patients with hepatocellular carcinoma,” Hepatology Research, vol. 34, no. 4, pp. 266–272, 2006. View at Publisher · View at Google Scholar · View at Scopus
- J. I. Tsao, J. P. Loftus, D. M. Nagomey, M. A. Adson, and D. M. Ilstrup, “Trends in morbidity and mortality of hepatic resection for malignancy: a matched comparative analysis,” Annals of Surgery, vol. 220, no. 2, pp. 199–205, 1994. View at Scopus
- M. Abu Hilal, A. Badran, F. di Fabio, and N. W. Pearce, “Pure laparoscopic en bloc left hemihepatectomy and caudate lobe resection in patients with intrahepatic cholangiocarcinoma,” Journal of Laparoendoscopic and Advanced Surgical Techniques A, vol. 21, no. 9, pp. 845–849, 2011. View at Publisher · View at Google Scholar · View at Scopus