Partial Preservation of Segment IV Confers No Benefit When Performing Extended Right Hepatectomy for Colorectal Liver Metastases

Table 1

Patient characteristics, operative details, and outcomes for 117 patients undergoing right-sided hepatectomy for colorectal liver metastases.

𝑁=117	Operation						𝑃 value
	Right hepatectomy; (𝑛=85)		Partially extended right; hepatectomy (𝑛=20)		Extended right; hepatectomy (𝑛=12)
	Count (%)	Median (range)	Count (%)	Median (range)	Count (%)	Median (range)	Partially extended versus right	Extended right versus right
Age		65 (33–82)		66 (40–88)		61 (54–77)	0.899	0.354
Gender
Female	35 (41.2)		7 (35.0)		5 (41.7)		0.800	1.000
Male	50 (58.8)		13 (65.0)		7 (58.3)
T stage of primary
0	1 (1.2)		1 (5.0)		0		0.326	1.000
1	2 (2.4)		0		0		1.000	1.000
2	4 (4.7)		2 (10.0)		2 (16.7)		0.290	0.144
3	48 (56.5)		12 (60.0)		6 (50.0)		0.600	1.000
4	28 (32.9)		3 (15.0)		3 (25.0)		0.258	1.000
N/A*	2 (2.4)		2 (10.0)		1 (8.3)		—	—
N stage of primary
0	39 (45.9)		7 (35.0)		3 (25.0)		0.608	0.335
1	21 (24.7)		7 (35.0)		6 (50.0)		0.257	0.072
2	23 (27.1)		4 (20.0)		2 (16.7)		0.774	0.721
N/A*	2 (2.4)		2 (10.0)		1 (8.3)		—	—
Preoperative Chemotherapy
Yes	50 (58.8)		10 (50.0)		9 (75.0)		0.616	0.356
No	35 (41.2)		10 (50.0)		3 (25.0)
Number of chemotherapy cycles		4 (2–11)		4 (1–4)		5 (1–6)	0.115	0.854
Synchronous bowel resection	1 (1.2)		0		1 (8.3)		1.000	0.233
Number of tumours		1.5 (1–9)		2; (1–7)		2.5; (1–8)	0.100	0.118
Maximum diameter (mm)		35; (5–120)		50; (11–155)		52.5; (17–150)	0.026^†	0.004^†
Pringle manoeuvre used	0		1 (5.0)		0		0.191	1.000
Blood loss
<500 mL	43 (50.6)		5 (25.0)		4 (33.3)		0.046^†	0.357
>500 mL	41 (48.2)		15 (75.0)		8 (66.7)
Not recorded	1 (1.2)		0		0
Postoperative lactate (mmol/L)		3.3; (1.2–15.0)		3.35; (1.7–11.6)		4.35; (2.4–5.2)	0.592	0.006^†
Bile leak	7 (8.2)		2 (10.0)		2 (16.7)		0.680	0.308
Renal dysfunction (POD 0–5)
Yes	10 (11.8)		3 (15.0)		0		0.710	0.355
No	75 (88.2)		17 (85.0)		12 (100)
Peak postoperative transaminase (iu/L)		376; (104–1557)		435; (92–2331)		309; (81–921)	0.356	0.289
PHLF on POD 5
Yes	13 (15.3)		4 (20.0)		1 (8.3)		0.508	1.000
No	72 (84.7)		15 (75.0)		11 (91.7)
N/A**			1 (5.0)
Length of stay (days)		8 (4–30)		8 (6–27)		8 (5–15)	0.613	0.629
90-day mortality
Yes	3 (3.5)		4 (20.0)		0		0.024^†	1.000
No	82 (96.5)		16 (80.0)		12 (100)
Death from liver failure
Yes	2 (2.4)		3 (15.0)		0		0.047^†	1.000
No	83 (97.6)		17 (85.0)		12 (100)

∗Primary pathology not available for 5 patients. **PHLF not applicable if patient died before POD 5. ^†Significant at the level of 𝑃<0.05.