Selective Interarterial Radiation Therapy (SIRT) in Colorectal Liver Metastases: How Do We Monitor Response?

Table 4

CEA responses to radioembolisation at 3 months.

Study	Number of patients	Definition of CEA reduction	Percentage of patients (%) with CEA reduction
Gray et al. 2001 [30]	36	≥50%	72
Wong et al. 2002 [16]	8	Statistically significant	75
Murthy et al. 2005 [29]	9	NR	57
Lewandowski et al. 2005 [35]	27	50%	38
		80%	19
Kennedy et al. 2006 [24]	208	NR	70
Stubbs et al. 2006 [22]	100	82%	96
Jakobs et al. 2007 [37]	18	NR	82
Boppudi et al. 2006 [23]	54	75%	70
Sharma et al. 2007 [5]	20	NR	100*
Nace et al. 2011 [31]	51 (41 patients’ levels recorded)	≥50%	41%
Kosmider et al. 2011 [32]	19	Median reduction 35%	100

NR: not recorded, *at 6 months.
The 23 patients in the van Hazel et al. [38] publication from 2009 also had a reduced CEA. Median serum CEA decreased by 82% in this trial where radioembolisation was used in conjunction with irinotecan chemotherapy.