Intraportal versus Systemic Pentoxifylline Infusion after Normothermic Liver Ischemia: Effects on Regional Blood Flow Redistribution and Hepatic Ischemia-Reperfusion Injury

Figure 1

(a) Cardiac output (L/min), (b) and (c) portal vein and hepatic artery blood flows (mL/min) during the experimental protocol. The animals were randomly assigned into three groups: CT (control, portal triad clamping, 𝑛=8), PTX-syst (portal triad clamping + 25 mg/Kg of PTX intravenous systemically, 𝑛=8), and PTX-pv (portal triad clamping + 25 mg/Kg of PTX in the portal vein, 𝑛=8). BL: baseline; P45: 45 min after Pringle’s maneuver; R15, R60, and R120: 15, 60, and 120 min after reperfusion. Data are shown as mean±SEM. ^aIndicates 𝑃<0.05 for PTX-pv and PTX-sys versus BL; ^bbindicates 𝑃<0.05 for PTX-pv and PTX-sys versus CT; ^cindicates 𝑃<0.05 for PTX-sys versus BL; ^dindicates 𝑃<0.05 for PTX-sys versus CT.

(a)

(b)

(c)