Intraportal versus Systemic Pentoxifylline Infusion after Normothermic Liver Ischemia: Effects on Regional Blood Flow Redistribution and Hepatic Ischemia-Reperfusion Injury

Table 1

Mean arterial and pulmonary artery pressures (MAP and MPAP, mmHg), arterial hemoglobin (g/dL), arterial pH in CT (control, portal triad clamping, 𝑛=8), PTX-syst (portal triad clamping + 25 mg/Kg of PTX intravenous systemically, 𝑛=8), and PTX-pv (portal triad clamping + 25 mg/Kg of PTX in the portal vein, 𝑛=8) groups.

	Group	BL	P45	R15	R60	R120
MAP mmHg	CT	100.5±20.4	91.0±21.5	83.3±25.2	67.5±26.4^a,b,c	73.5±29.4^a
	PTX-syst	115.3±17.7	85.0±22.2	94.1±21.5	80.2±18.3^a	87.0±31.2
	PTX-pv	111.6±21.4	84.0±14.8	89.2±20.6	78.0±14.7^a	87.2±19.2
MPAP mmHg	CT	15.6±2.2	16.8±2.8	16.2±3.9	15.0±4.2	13.0±3.6
	PTX-syst	14.7±3.7	14.6±5.0	16.1±3.2	14.0±2.6	13.7±2.8
	PTX-pv	15.6±4.8	16.5±5.2	17.5±5.7	16.4±5.1	15.7±4.9
Hemoglobin g/dL	CT	12.9±2.1	10.2±2.4	10.5±2.8	11.4±3.1	11.4±3.2
	PTX-syst	13.6±1.7	11.2±2.0	11.1±2.2	10.4±2.2	10.3±2.7
	PTX-pv	12.9±1.7	10.4±1.7	10.4±1.2	10.1±1.5	9.6±1.4
Arterial pH	CT	7.36±0.06	7.30±0.07	7.23±0.05^a	7.21±0.07^a	7.21±0.05^a
	PTX-syst	7.41±0.06	7.32±0.08	7.25±0.09^a	7.24±0.11^a	7.24±0.11^a
	PTX-pv	7.36±0.07	7.28±0.06	7.22±0.07^a	7.24±0.09^a	7.24±0.08^a

Legends: BL: baseline; P45: 45 min after Pringle’s maneuver; R15, R60, and R120: 15, 60, and 120 min after reperfusion. Data are shown as mean ± SEM. ^aIndicates 𝑃<0.05 versus BL; ^bindicates 𝑃<0.05 versus PTX-sys; ^cindicates 𝑃<0.05 versus PTX-pv.