Metabolomic Analysis of Liver Tissue from the VX2 Rabbit Model of Secondary Liver Tumors

Table 3

Table below shows the differentially expressed metabolites for the site effect (distant versus adjacent biopsy) in the treatment group alone (LT− versus LT+) with at most 10% FDR. Metabolites are ranked from top to bottom by (1) statistical significance (𝐵) and (2) magnitude of change (𝑀).

(a) 14 downregulated

Down-regulated
	ID	𝑀=log2(FC)	FDR Adj.	𝐵=log2(Odds)
			𝑃 values
1	Uracil	−3.00112	3.83𝐸−35	83.65428
2	Erythriol	−2.70968	9.69𝐸−30	68.06919
3	𝛼-Hydroxyglutaric acid	−1.626	2.75𝐸−12	24.07396
4	Salicylic acid	−1.43637	4.63𝐸−10	18.63641
5	Ethanolamine	−1.11231	1.17𝐸−06	10.90255
6	Amino ethyl phosphate	−0.64698	0.004687	3.236894
7	D-Ribose-5-phosphate	−0.556	0.013184	2.212044
8	Citrate	−0.54086	0.014689	2.056548
9	𝛽-Alanine	−0.48647	0.025933	1.533321
10	Glycolic acid	−0.41113	0.050703	0.900165
11	Glycine	−0.39026	0.058594	0.743548
12	L-Alanine	−0.33772	0.085378	0.385349
13	L-Serine	−0.33726	0.085378	0.382457
14	Aminomalonic acid	−0.31862	0.095196	0.267971

(b) 6 up-regulated

Up-regulated
	ID	𝑀=log2(FC)	FDR Adj.	𝐵=log2(Odds)
			𝑃-values
1	Glucose	2.477314	1.30𝐸−25	56.78349
2	Glycerol	1.546767	2.37𝐸−11	21.72003
3	Threonic acid	1.349669	4.13𝐸−09	16.37445
4	Glycerol-3-P	0.733706	0.001424	4.35813
5	Inositol	0.56952	0.012116	2.354559
6	O-acetylsalicylic acid	0.447728	0.037053	1.194456