Preoperative Gadoxetic Acid-Enhanced MRI and Simultaneous Treatment of Early Hepatocellular Carcinoma Prolonged Recurrence-Free Survival of Progressed Hepatocellular Carcinoma Patients after Hepatic Resection
Table 2
Univariate analysis of clinical and laboratory factors for overall and recurrence-free survival after hepatic resection for HCC.
Variable
Number of patients
Overall survival
Recurrence-free survival
HR
95% CI
value
HR
95% CI
value
Sex
Male
110
1
1
Female
37
0.81
0.37–1.79
0.61
0.66
0.39–1.16
0.13
Age (years)
≦70
85
1
1
>70
62
1.01
0.97–1.04
0.78
1.33
0.86–2.03
0.2
EOB-MRI
Absent
70
1
1
Present
77
0.72
0.34–1.15
0.38
0.57
0.37–0.87
<0.01
History of blood transfusion
Absent
109
1
1
Present
38
1.4
0.69–2.87
0.35
1.18
0.73–1.90
0.48
Alcoholism
Absent
79
1
1
Present
68
1.4
0.72–2.72
0.32
1.34
0.88–2.05
0.17
Smoking
Absent
52
1
1
Present
95
1.66
0.80–3.45
0.17
1.24
0.79–1.94
0.34
Diabetes mellitus
Absent
103
1
1
Present
44
1.5
0.76–2.93
0.24
1.32
0.85–2.07
0.22
Esophageal varix
Absent
118
1
1
Present
29
2.39
1.17–4.91
0.02
1.24
0.73–2.11
0.44
Albumin (g/dL)
≦3.5
19
1
1
>3.5
128
0.5
0.23–1.10
0.08
0.49
0.28–0.84
<0.01
Total bilirubin (mg/dL)
≦1.0
133
1
1
>1.0
14
0.42
0.10–1.78
0.24
0.71
0.34–1.49
0.36
Alanine aminotransferase (IU/L)
≦30
59
1
1
>30
88
1.44
0.71–2.95
0.31
1.5
0.96–2.34
0.08
Platelets (×104/L)
≦10
33
1
1
>10
114
0.27
0.27–0.52
<0.01
0.6
0.37–0.97
0.04
Indocyanine green retention rate at 15 minutes (%)
≦15
77
1
1
>15
70
1.78
0.90–3.50
0.1
1.13
0.74–1.71
0.58
Prothrombin time (%)
≦80
71
1
1
>80
76
0.59
0.30–1.17
0.13
0.71
0.47–1.10
0.11
Child-Pugh classification
A
137
1
1
B
10
3.68
1.51–8.93
<0.01
2.65
1.32–5.32
<0.01
Alpha-fetoprotein (ng/mL)
≦100
117
1
1
>100
30
0.71
0.29–1.71
0.44
0.71
0.41–1.24
0.23
AFP-L3 (%)
≦10
110
1
1
>10
36
0.97
0.46–2.08
0.94
0.79
0.47–1.31
0.36
Des--carboxy prothrombin (mAU/mL)
≦40
76
1
1
>40
68*
2.14
1.08–4.22
0.03
1.4
0.91–2.14
0.12
Hepatitis B surface antigen
Negative
115
1
1
Positive
32
0.97
0.44–2.14
0.94
0.62
0.35–1.10
0.09
Hepatitis C antibody
Negative
61
1
1
Positive
86
1.42
0.71–2.86
0.33
1.56
1.01–2.42
<0.05
Three patients were excluded because of warfarin administration.