Preoperative Gadoxetic Acid-Enhanced MRI and Simultaneous Treatment of Early Hepatocellular Carcinoma Prolonged Recurrence-Free Survival of Progressed Hepatocellular Carcinoma Patients after Hepatic Resection

Table 2

Univariate analysis of clinical and laboratory factors for overall and recurrence-free survival after hepatic resection for HCC.

Variable	Number of patients	Overall survival			Recurrence-free survival
		HR	95% CI	𝑃 value	HR	95% CI	𝑃 value
Sex
Male	110	1			1
Female	37	0.81	0.37–1.79	0.61	0.66	0.39–1.16	0.13
Age (years)
≦70	85	1			1
>70	62	1.01	0.97–1.04	0.78	1.33	0.86–2.03	0.2
EOB-MRI
Absent	70	1			1
Present	77	0.72	0.34–1.15	0.38	0.57	0.37–0.87	<0.01
History of blood transfusion
Absent	109	1			1
Present	38	1.4	0.69–2.87	0.35	1.18	0.73–1.90	0.48
Alcoholism
Absent	79	1			1
Present	68	1.4	0.72–2.72	0.32	1.34	0.88–2.05	0.17
Smoking
Absent	52	1			1
Present	95	1.66	0.80–3.45	0.17	1.24	0.79–1.94	0.34
Diabetes mellitus
Absent	103	1			1
Present	44	1.5	0.76–2.93	0.24	1.32	0.85–2.07	0.22
Esophageal varix
Absent	118	1			1
Present	29	2.39	1.17–4.91	0.02	1.24	0.73–2.11	0.44
Albumin (g/dL)
≦3.5	19	1			1
>3.5	128	0.5	0.23–1.10	0.08	0.49	0.28–0.84	<0.01
Total bilirubin (mg/dL)
≦1.0	133	1			1
>1.0	14	0.42	0.10–1.78	0.24	0.71	0.34–1.49	0.36
Alanine aminotransferase (IU/L)
≦30	59	1			1
>30	88	1.44	0.71–2.95	0.31	1.5	0.96–2.34	0.08
Platelets (×10^4/𝜇L)
≦10	33	1			1
>10	114	0.27	0.27–0.52	<0.01	0.6	0.37–0.97	0.04
Indocyanine green retention rate at 15 minutes (%)
≦15	77	1			1
>15	70	1.78	0.90–3.50	0.1	1.13	0.74–1.71	0.58
Prothrombin time (%)
≦80	71	1			1
>80	76	0.59	0.30–1.17	0.13	0.71	0.47–1.10	0.11
Child-Pugh classification
A	137	1			1
B	10	3.68	1.51–8.93	<0.01	2.65	1.32–5.32	<0.01
Alpha-fetoprotein (ng/mL)
≦100	117	1			1
>100	30	0.71	0.29–1.71	0.44	0.71	0.41–1.24	0.23
AFP-L3 (%)
≦10	110	1			1
>10	36	0.97	0.46–2.08	0.94	0.79	0.47–1.31	0.36
Des-𝛾-carboxy prothrombin (mAU/mL)
≦40	76	1			1
>40	68*	2.14	1.08–4.22	0.03	1.4	0.91–2.14	0.12
Hepatitis B surface antigen
Negative	115	1			1
Positive	32	0.97	0.44–2.14	0.94	0.62	0.35–1.10	0.09
Hepatitis C antibody
Negative	61	1			1
Positive	86	1.42	0.71–2.86	0.33	1.56	1.01–2.42	<0.05

∗Three patients were excluded because of warfarin administration.