The Association between Survival and the Pathologic Features of Periampullary Tumors Varies over Time

Table 2

Multivariate logistic regression analyses between clinicopathologic features and one- and three-year mortality following surgical resection.

Covariate	1-year mortality				3-year mortality
	Odds ratio	95% CI	𝑃	Pseudo 𝑅^2	Odds ratio	95% CI	𝑃	Pseudo 𝑅^2
Model A
Age	1.04	1–1.08	0.027	0.108	1.02	0.99–1.05	0.225	0.129
Tumor size	1.51	1.17–1.95	0.001		1.56	1.19–2.04	0.001
Margin status	2.64	1.34–5.2	0.005		4.14	1.89–9.08	<0.001
Model B
Age	1.04	1.01–1.08	0.022	0.123	1.02	0.99–1.06	0.144	0.206
Tumor size	1.53	1.18–1.98	0.001		1.6	1.21–2.12	0.001
Margin status	2.32	1.16–4.65	0.017		3.3	1.44–7.55	0.005
Lymphovascular invasion	1.91	0.96–3.82	0.066		4.51	2.24–9.07	<0.001
Model C
Age	1.04	1–1.08	0.026	0.122	1.02	0.99–1.05	0.168	0.195
Tumor size	1.49	1.15–1.93	0.003		1.62	1.21–2.16	0.001
Margin status	2.06	1–4.25	0.052		2.5	1.08–5.81	0.032
Perineural invasion	2.09	0.91–4.84	0.083		4.37	2.09–9.13	<0.001
Model D
Age	1.04	1.01–1.08	0.022	0.129	1.02	0.99–1.05	0.18	0.225
Tumor size	1.45	1.11–1.88	0.006		1.5	1.12–2	0.006
Margin status	2.24	1.12–4.5	0.023		3.39	1.46–7.89	0.005
LN status	2.39	1.07–5.35	0.034		5.51	2.71–11.2	<0.001
Model E
Age	1.04	1.01–1.08	0.017	0.133	1.02	0.99–1.05	0.236	0.202
Tumor size	1.45	1.12–1.88	0.005		1.43	1.09–1.89	0.011
Margin status	2.21	1.09–4.46	0.028		3.31	1.44–7.61	0.005
LNR (%)	1.02	1–1.04	0.017		1.07	1.03–1.11	0.001

LN: lymph nodes; LNR (lymph node ratio) = (number of positive LN)/(total LN removed) * 100.