The Association between Survival and the Pathologic Features of Periampullary Tumors Varies over Time

Table 3

Cox regression multivariate analysis between pathologic features and overall survival.

Covariate	Number of patients	Hazard ratio	95% CI	𝑃
Model A
Age	206	1.02	1–1.04	0.019
Tumor size		1.31	1.16–1.48	<0.001
Margin status		2.12	1.5–3.01	<0.001
Model B
Age	206	1.02	1–1.04	0.018
Tumor size		1.35	1.19–1.52	<0.001
Margin status		1.69	1.17–2.44	0.005
Lymphovascular invasion		1.96	1.37–2.82	<0.001
Model C
Age	206	1.02	1–1.04	0.014
Tumor size		1.3	1.15–1.47	<0.001
Margin status		1.58	1.09–2.29	0.016
Perineural invasion		2.19	1.44–3.32	<0.001
Model D
Age	206	1.02	1.01–1.04	0.008
Tumor size		1.27	1.12–1.43	<0.001
Margin status		1.75	1.23–2.5	0.002
LN status		2.44	1.64–3.64	<0.001
Model E
Age	206	1.02	1–1.04	0.012
Tumor size		1.28	1.13–1.45	<0.001
Margin status		1.95	1.37–2.76	<0.001
LNR (%)		1.02	1.01–1.03	<0.001

LN: lymph nodes; LNR (lymph node ratio) = (number of positive LN)/(total LN removed) * 100.