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Infectious Diseases in Obstetrics and Gynecology
Volume 1 (1994), Issue 5, Pages 242-245
Pregnancy Outcome in Swiss-Webster Mice Infected With Chlamydia trachomatis
1Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Texas Health Science Center, Houston, TX, USA
2Department of Obstetrics and Gynecology, Loma Linda University, Loma Linda, CA, USA
3Department of Perinatology, McKay-Dee Hospital Center, 3939 Harrison Boulevard, Ogden 84409, UT, USA
Received 15 November 1993; Accepted 11 March 1994
Copyright © 1994 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Objective: The objective of this study was to observe pregnancy outcomes in mice infected transvaginally with Chlamydia trachomatis.
Methods: Pregnant mice were inoculated transvaginally with either C. trachomatis (CT) or sterile calf serum (CON) on pregnancy day 4. Pregnancy outcomes as well as genital tract histology and culture were compared. Statistical analysis was performed using Fisher's exact test and Student's t-test.
Results: Twenty-four of 26 CT mice had positive uterine cultures for C. trachomatis. Inflammation occurred in 9 (34.6%) (P = 0.002, 95% confidence interval = 1.7–3.5) and intrauterine fetal demise occurred in 5 (19.2%) (P = 0.05, 95% confidence interval = 1.6–2.9) of CT mice. No mice in the CON group (0/24) had positive uterine cultures, developed inflammation, or experienced intrauterine fetal demise.
Conclusions: Lower genital tract chlamydial infection is associated with intrauterine fetal demise in Swiss-Webster mice.