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Infectious Diseases in Obstetrics and Gynecology
Volume 2 (1994), Issue 3, Pages 115-119
Comparison of Culture and Rapid Enzyme Immunoassay for the Detection of Group B Streptococcus in High-Risk Pregnancies
Departments of Obstetrics and Gynecology and Pathology, Medical College of Virginia/Virginia Commonwealth University, Box 980034 MCV Station, Richmond, VA 23298, USA
Received 8 March 1994; Accepted 24 May 1994
Copyright © 1994 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Objective: The purpose of this study was to evaluate the Equate Strep B® test for clinical use in patients at high risk for complications from group B streptococcus (GBS) disease.
Methods: Vaginoperineal swabs were obtained from patients with preterm premature rupture of the membranes and/or preterm labor and semiquantitative GBS cultures and Equate® assay were performed.
Results: From May 14, 1990, to April 30, 1992, 650 patients were enrolled; 626 had both culture and Equate® results available, of whom 24% were colonized with GBS. The sensitivity, specificity, positive predictive value, and negative predictive value of the rapid assay were 28%, 84%, 35%, and 79%, respectively. Although the prevalence of GBS was higher in patients with ruptured membranes compared with those with intact membranes, rupture of membranes did not affect test sensitivity or specificity.
Conclusions: We conclude that the Equate® rapid assay is not a sensitive method of GBS detection in high-risk patients.