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Infectious Diseases in Obstetrics and Gynecology
Volume 5 (1997), Issue 1, Pages 18-22
Evaluation of 3-Day Course of Doxycycline for the Treatment of Uncomplicated Chlamydia trachomatis Cervicitis
1Department of Obstetrics and Gynecology, Scott & White Clinic, 1600 University Drive East, College Station 77840, TX, USA
2Texas A&M University Health Sciences Center, College of Medicne, Temple, TX, USA
3Department of Biostatistics, Scott & White Clinic, Temple, TX, USA
4Department of Pathology, Scott & White Clinic, College Station and Temple, TX, USA
5Department of Medical Biochemistry and Genetics, Scott & White Clinic, College Station and Temple, TX, USA
Received 20 September 1996; Accepted 3 March 1997
Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Objective: The purpose of this study was to compare the efficacy of a 3-day course of doxycycline to a standard 7-day course for treating uncomplicated chlamydia cervicitis.
Methods: During an 18-month period, 77 women with uncomplicated chlamydia cervicitis were randomized to receive either a 3-day or a 7-day course of doxycycline (100 mg twice daily). Tests of cure were performed 3 weeks after completion of therapy with the Amplicor polymerase chain reaction (PCR) assay (Roche Molecular Systems, Branchburg, NJ). Demographics, therapeutic results, and side effects for the two groups were compared.
Results: Seventy-three patients completed the study: 35 in the 3-day group and 38 in the 7-day group. There were no significant differences in age, gravidity, or parity between the groups. There was a 94% (33/35) cure rate in the 3-day group and a 95% (36/38) cure rate in the 7-day group (P = 1.0). Thirty-four percent and 32% of the patients in the 3- and 7-day groups reported side effects, respectively; there was no significant differences between the 3- and 7-day groups in regard to population demographics, patient compliance, therapeutic outcome, or side effects.
Conclusions: A 3-day course of doxycycline appears to be as effective as a 7-day course of doxycycline for the treatment of uncomplicated chlamydia cervicitis.