The Metabolism and Transplacental Transfer of Oseltamivir in the Ex Vivo Human Model

Table 1

Mean maternal and fetal concentrations of oseltamivir phosphate and oseltamivir carboxylate from 6 term placental cotyledons perfused with supratherapeutic concentrations of oseltamivir phosphate.

	Maternal (ng/ml)		Fetal (ng/ml)
Placenta	OP^∗	OC	OP	OC
1	320 (5x)	ND	ND	ND
2	400 (6x)	ND	ND	ND
3	1 300 (20x)	86	ND	4.3
4	2 160 (30x)	140	30	5
5	51 000 (780x)	90	7300	9
6	54 000 (830x)	96	3300	2.4

∗concentration relative to therapeutic dose in parentheses.
ND = nondetectable.