Kinetics and Determining Factors of the Virologic Response to Antiretrovirals during Pregnancy

Figure 1

Kinetics of the plasma HIV RNA in pregnant women on HAART. Data were derived from 76 pregnant women who initiated or reinitiated HAART during pregnancy. 0 weeks indicates the beginning of therapy. Grey lines represent individual plasma HIV RNA trajectories. The black line represents the population curve generated by the mixed-model analysis. The predictions of the model were confirmed by additional analyses which showed that at 4 weeks of HAART, 42% of mothers had <100 HIV RNA copies/mL of plasma; at 12 weeks, 42% had <50 copies/mL; and at 24 weeks, 56% had <50 copies/mL. However, it should be noted that the model’s estimated rise between 5 and 7 weeks is likely not real.