Pretreatment with Pancaspase Inhibitor (Z-VAD-FMK) Delays but Does Not Prevent Intraperitoneal Heat-Killed Group B Streptococcus-Induced Preterm Delivery in a Pregnant Mouse Model
Figure 1
Intrauterine HK-GBS injection leads to TUNEL positive apoptosis in the membranes. Day 14.5 timed pregnant mice were injected with either HK-GBS (panel d) or PBS (a) and euthanized at 5 or 14 hours to isolate the placenta and membranes. The sections shown were obtained after 14 hours of stimulation. TUNEL positive apoptotic cells are stained black-brown. Slides treated with endonuclease served as a positive control (b); animals injected with media indicate baseline apoptosis levels (c). Data shown are representative of 3 separate experiments.
