Cost-Effectiveness of Universal Prophylaxis in Pregnancy with Prior Group B Streptococci Colonization

Table 2

Costs (in 2008 USD) included in decision tree.

Variable	Baseline estimate	Range for sensitivity analysis	Source or references
Cost of GBS rectal-vaginal culture
	$50	$30–$75	[8, 18, 32, 34, 41]
Cost of GBS rectal-vaginal culture with susceptibility testing			[34]
	$59	$35–$89	[36]
Cost of maternal antibiotic therapy
One dose of 5 million units of penicillin G
	$18	$9–$27
Second dose of 2.5 million units of penicillin G
	$11	$6–$17
One dose of 2 grams of cefazolin
	$14	$7–$21
One dose of 900 milligrams of clindamycin
	$18	$9–$27
One dose of 500 milligrams of erythromycin
	$16	$8–$24
One dose of 1 gram of vancomycin
	$12	$6–$18
Cost of neonatal CBC			[22, 34, 38, 39]
	$15	$8–$41
Cost of neonatal blood culture			[22, 34, 40]
	$20	$10–$26
Cost of maternal anaphylaxis case
	$11 160	$1186–$30 286	[8, 33, 38, 39]
Cost of maternal death due to anaphylaxis
	$1 211 432	$1 090 288–$1 332 575	[8]
Direct cost of early onset GBS sepsis case term infant
	$19 774	$17 723–$21 824	[38, 39, 41]
Total (direct and indirect) cost of early onset GBS sepsis case term infant
	$81 599	$67 764–$95 433	[38, 39, 42]

GBS: group B streptococci; CBC: complete blood count.