Leukemia Inhibitory Factor Downregulates Human Papillomavirus-16 Oncogene Expression and Inhibits the Proliferation of Cervical Carcinoma Cells
Figure 2
(a) SiHa cells were stimulated with LIF (10 ng/mL) for the times indicated (in minutes), and the level of phospho-STAT3(y705) measured. STAT3 is transiently phosphorylated following stimulation with LIF within 60 minutes, returning to baseline level by 120 minutes. Histograms are colored according to the log10-fold increase in mean fluorescence intensity relative to unstimulated cells. (b) CaSki cells transfected with a STAT3 reporter plasmid were treated with 50 ng/mL LIF for 6 hours prior to assay. The increase in relative light units is shown. Error bars represent standard error of the mean. Asterisks represent significance (**).
