Infectious Diseases in Obstetrics and Gynecology / 2011 / Article / Tab 1 / Review Article
Antichlamydial Antibodies, Human Fertility, and Pregnancy Wastage Table 1 Role of antichlamydial antibody testing in male and female fertility.
Method Sens. (%) Specif. (%) PPV (%) NPV (%) Utility in females Utility in males CT IgG [22 ] ELISA 72.7 77.7 — — Presence indicates previous or persistent C. trachomatis infection; associated with tubal damage; increased titers associated with more severe tubal damage; sens./specif. may be increased with the addition of HSG or laparoscopy — CT IgG [33 ] ELISA 43.2 86.5 63.3 73.8 — CT IgG [6 ] MIF 74 93 94.8 69.8 — CT IgG [5 ] EIA 45 83 — — — CT IgG [23 ] Titer
1 : 256 WIF 69 85 78 78 — CT HSP60 [33 ] ELISA 59.1 77.9 59.1 77.9 Reflects chronic C. trachomatis infection; predicts TFI — CT HSP60 [7 ] GST ELISA 56 95 — — Higher titers related to increased severity of tubal damage — +ClpP Ab [7 ] GST ELISA 69 — 92 79 Improve sens./specif. in Ab based diagnosis of TFI — CT IgA [28 , 29 ] MIF/EIA — — — — — Reduces chances of achieving pregnancy; reduced motility of spermatozoa, increased number of dead spermatozoa +CT IgG [28 , 29 ] MIF/EIA — — — — — Further reduce pregnancy rates, decrease sperm concentration, decrease number of progressive spermatozoa CT HSP60 [29 ] ELISA — — — — — Reduce spermatozoa motility
ELISA: enzyme-linked immunosorbent assay, EIA: enzyme immunoassay, WIF: whole-cell inclusion immunofluorescence assay, GST ELISA: glutathione S -transferase ELISA, MIF: microimmunofluorescence, Ab: antibody; Sens.: sensitivity, Specif.: specificity, PPV: positive predictive value, NPV: negative predictive value; TFI: tubal factor infertility; HSG: hysterosalpingogram.