Research Article
Clinicopathological Comparison of Adenocarcinoma of Cervix and Endometrium Using Cell Cycle Markers: P16ink4a, P21waf1, and p27Kip1 on 132 Cancers
Table 4
Associations between p16INK4a expression and clinicopathologic parameter for endocervical adenocarcinoma.
| | Characteristics | No. of patients | Positive, (%) () | Negative, (%) () | value |
| | Age (years) | | | | | | <35 | 3 | 2 (66.7) | 1 (33.3) | 0.256 | | 35–54 | 22 | 16 (72.7) | 6 (27.3) | | ≥55 | 15 | 14 (93.3) | 1 (6.7) |
| | FIGO stage | | | | | | I-II | 30 | 24 (80.0) | 6 (20.0) | 1.000 | | III-IV | 10 | 8 (80.0) | 2 (20.0) |
| | Histology tumor differentiation | | | | | | Well/moderate | 25 | 18 (72.0) | 7 (28.0) | 0.102 | | Poor | 15 | 14 (93.3) | 1 (6.7) |
| | Infiltration depth | | | | | | Inner 2/3 | 13 | 9 (69.2) | 4 (30.8) | 0.237 | | Outer 1/3 or through | 27 | 23 (85.2) | 4 (14.8) |
| | Tumor size ([diameter) | | | | | | <20 mm | 11 | 8 (72.7) | 3 (27.3) | 0.479 | | >20 mm | 29 | 24 (82.8) | 5 (17.2) |
| | Tumor thickness | | | | | | <5 mm | 4 | 3 (75.0) | 1 (25.0) | 0.792 | | >5 mm | 36 | 29 (80.6) | 7 (19.4) |
| | Infiltration to corpus | | | | | | Yes | 17 | 13 (76.5) | 4 (23.5) | 0.631 | | No | 23 | 19 (82.6) | 4 (17.4) |
| | Vascular invasion | | | | | | Yes | 20 | 17 (85.0) | 3 (15.0) | 0.429 | | No | 20 | 15 (75.0) | 5 (25.0) |
| | Lymph node invasion | | | | | | Yes | 12 | 8 ( 66.7) | 4 (33.3) | 0.168 | | No | 28 | 24 (85.7) | 4 (14.3) |
| | Histologic type | | | | | | Endocervical | 25 | 20 (80.0) | 5 (20.0) | 1.000 | | Non endocervical | 15 | 12 (80.0) | 3 (20.0) |
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