Atypical Squamous Cells of Undetermined Significance: Bethesda Classification and Association with Human Papillomavirus

Table 5

Presence of CIN II/III in biopsies, in relation to positivity for high-risk HPV through hybrid capture, and reclassification of ASCUS cytology according to Bethesda 2001.

Cytology	High-risk HPV positive			High-risk HPV negative
	Biopsy with CIN II/III 𝑁 (%)	Biopsy without CIN II/III; 𝑁 (%)	Biopsy not performed; 𝑁 (%)	Biopsy with CIN II/III; 𝑁 (%)	Biopsy without CIN II/III; 𝑁 (%)	Biopsy not; performed 𝑁 (%)
ASC-US	1 (20.0)	7 (70.0)	6 (50.0)	0	14 (63.6)	34 (68.0)
ASC-H	4 (80.0)*	1 (10.0)	0	1 (100.0)	2 (9.0)	0
Normal	0	2 (20.0)	6 (50.0)	0	6 (27.3)	16 (32.0)
Total	5	10	12	1	22	50

* 𝑃=.0319, presence of CIN II/III at biopsy versus ASC-US among patients who tested positive for high-risk HPV, Fisher’s exact test.