Promoter Methylation of p16INK4A, hMLH1, and MGMT in Liquid-Based Cervical Cytology Samples Compared with Clinicopathological Findings and HPV Presence
Table 1
Promoter methylation results.
MGMT
hMLH1
p16INK4A
Any gene
M
(%)
N
M
(%)
N
M
(%)
N
p
M
(%)
N
Cytology
WNL
22
22.7
97
***
5
5.7
88
*
7
13.5
52
31
32.0
97
***
ASCUS
26
40.7
64
4
7.0
57
9
18.4
49
33
51.6
64
LgSIL
51
38.6
132
22
17.9
123
18
17.5
103
75
56.8
132
ASC-H
3
37.5
8
1
14.3
7
1
33.3
3
4
50.0
8
HgSIL
43
47.3
91
13
14.8
88
15
19.7
76
54
59.3
91
SCC
5
80.0
6
0
0
5
1
33.3
3
5
83.3
6
AdenoCa
5
100
5
2
50.0
4
3
75.0
4
5
100
5
Colposcopy
NSF
3
42.9
7
***
0
0
7
*
0
0
5
3
42.9
7
***
Negative
25
27.2
93
6
7.3
82
11
21.2
52
35
38.0
93
LGSIL
74
38.7
191
24
13.6
177
25
17.6
142
100
52.4
191
HGSIL
40
40.8
98
15
16.1
93
15
18.5
81
56
57.1
98
SCC
9
81.8
11
1
10.0
10
1
14.3
7
9
81.8
11
AdenoCa
4
100
4
1
33.3
3
2
66.7
3
4
100
4
Histology
Negative
13
22.8
57
***
8
15.1
53
5
12.2
41
21
36.8
57
**
LSIL
70
42.7
164
21
13.5
155
25
20.7
121
95
57.9
164
HSIL
43
42.6
101
14
14.6
96
15
17.6
85
57
56.4
101
SCC
8
66.7
12
1
9.1
11
1
12.5
8
8
66.7
12
AdenoCa
6
100
6
2
40.0
5
3
75.0
4
6
100
6
M: Methylated, N: Number of cases, NSF: Nonsatisfactory, χ 2 for trend : *, **, ***.