Research Article

Promoter Methylation of p16INK4A, hMLH1, and MGMT in Liquid-Based Cervical Cytology Samples Compared with Clinicopathological Findings and HPV Presence

Table 1

Promoter methylation results.

MGMThMLH1p16INK4AAny gene
M(%)N M(%)N M(%)NpM(%)N

CytologyWNL2222.797 *** 55.788 * 713.5523132.097 ***
ASCUS2640.76447.057918.4493351.664
LgSIL5138.61322217.91231817.51037556.8132
ASC-H337.58114.37133.33450.08
HgSIL4347.3911314.8881519.7765459.391
SCC580.06005133.33583.36
AdenoCa51005250.04375.0451005

ColposcopyNSF342.97 *** 007 * 005342.97 ***
Negative2527.29367.3821121.2523538.093
LGSIL7438.71912413.61772517.614210052.4191
HGSIL4040.8981516.1931518.5815657.198
SCC981.811110.010114.37981.811
AdenoCa41004133.33266.7341004

HistologyNegative1322.857 *** 815.153512.2412136.857 **
LSIL7042.71642113.51552520.71219557.9164
HSIL4342.61011414.6961517.6855756.4101
SCC866.71219.111112.58866.712
AdenoCa61006240.05375.0461006

M: Methylated, N: Number of cases, NSF: Nonsatisfactory, χ 2 for trend : * , ** , *** .