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Infectious Diseases in Obstetrics and Gynecology
Volume 2011 (2011), Article ID 942937, 9 pages
http://dx.doi.org/10.1155/2011/942937
Review Article

Screening for Cytomegalovirus during Pregnancy

Medical College of Virginia Campus, Virginia Commonwealth University, P.O. Box 980163, Richmond, VA 23298-0163, USA

Received 31 January 2011; Revised 31 March 2011; Accepted 25 May 2011

Academic Editor: Grace John-Stewart

Copyright © 2011 Stuart P. Adler. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The epidemiology and pathogenesis of CMV infections among pregnant women have been intensely studied over the last three decades. This paper highlights recent developments that make either universal or limited serologic screening for CMV during pregnancy potentially attractive. The developments include an understanding of the pathogenesis of CMV infections, a knowledge of high-risk women, the availability of accurate methods for the serologic diagnosis of a primary CMV infection using either single or serial blood samples, accurate methods for the diagnosis of fetal infection via amniotic fluid, sensitive fetal and placental indicators for neonatal outcomes, and the availability of potentially effective interventions.