Study
Antibiotic regimen Gestational age at treatment(wks) Days treatment Primary outcomes Benefit Beta lactams Newton et al. (1991) [41 ] 91 IV ampicillin/sulbactam + PO indomethacin Less than 36 3 (1) Gestational age at delivery No Cox et al. (1995) [42 ] 78 IV ampicillin/sulbactam + PO amoxicillin-clavulanate 24–34 7 Mean gestational age at delivery No Gordon et al. (1995) [43 ] 117 IV ceftizoxime 24–35 5 Prolongation of gestation No Clindamycin McGregor et al. (1991) [44 ] 117 IV and PO clindamycin Less than 34 7 Interval to delivery Yes
) Lamont et al. (2003) [45 ] 409 2% clindamycin cream(vaginal) 13–20 3 Incidence of preterm birth Yes
) Kekki et al. (2001) [46 ] 5432 2% clindamycin cream (vaginal) 10–17 7 (1) Rates of preterm delivery No Azithromycin Van de Broek et al. (2009) [47 ] 2297 PO azithromycin 16–24 and 28–32 2 doses Incidence of preterm birth No Combination regimens Norman et al. (1994) [48 ] 81 IV ampicillin/PO amoxicillin + PO metronidazole 26–34 5 (1) Days gained Yes
) Svare et al. (1997) [49 ] 112 IV ampicillin/PO pivampicin + PO metronidazole 26–34 7 (1) Days to delivery Yes
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) Newton et al. (1989) [50 ] 103 IV Ampicillin/PO erythromycin 24–35 7 (1) Rate of preterm birth No Romero et al. (1993) [51 ] 277 IV Ampicillin/erythromycin + PO amoxicillin/erythromycin 24–34 7 (1) Time to delivery No Oracle II (2001) [52 ] 6295 PO erythromycin or PO amoxicillin-clavulanate or both Less than 37 10 Composite neonatal morbidity or mortality No
