Effect of HSV-2 Suppressive Therapy on Genital Tract HIV-1 RNA Shedding among Women on HAART: A Pilot Randomized Controlled Trial

Table 4

Association between selected covariates and GT HIV-1 RNA shedding.

	OR (95% CI)	𝑃 value
Detectable HSV-2 DNA
Between-subject	5.68 (0.82, 39.18)	0.08
within-subject	3.35 (1.44, 7.81)	<0.01
Bacterial Vaginosis
Between-subject	2.29 (1.01, 5.16)	0.05
within-subject	2.36 (1.10, 5.07)	0.03
GT WBC greater than 100 cells/mm^3
Between-subject	2.11 (0.83, 5.39)	0.12
within-subject	1.84 (0.94, 3.60)	0.07
Missing ARV dose in past two weeks
Between-subject	2.37 (0.66, 8.45)	0.19
within-subject	2.16 (1.14, 4.10)	0.02

NOTE. GT, GT; RNA, ribonucleic acid; HSV, herpes simplex virus; DNA, deoxyribonucleic acid; WBC, white blood cell; ARV, antiretroviral therapy.