Research Article

Prenatal Ultrasound Screening for Fetal Anomalies and Outcomes in High-Risk Pregnancies due to Maternal HIV Infection: A Retrospective Study

Table 4

Fetal and neonatal malformation/chromosomal anomalies.

HAARTDiagnosis prenatallyEarly scan (first trimester)Detailed scan (second trimester)Diagnosis postnatallyInvasive testing/KaryotypeMaternal coinfectionDuration of pregnancy in weeks + daysOutcome

CBV TDF T20CDHNoYesCDHNoHCV After operation alive and well

CBV NVPVSDYesYesVSDNoHCV HBV MTCT

CBV NVPHydrocephalus, radial deviation of handsNoYesconfirmedYes (normal Karyotype)No Died at 1 day

CBV NVPDandy Walker malformationNoYesconfirmedPostnatally unbalanced translocation1No Died with 3 months

TVD AZTMCDK Potter 2aNoYesconfirmedYesNo Alive and well

CBV NVPHeart defect (ASD and dextrocardia)NoYesconfirmedNoNo Alive and well

TDF NVP 3TCNoYesYesSkin tag (manubrium)NoNo Alive and well

TVD AZTNoYesYesSkin tag (finger)NoNo Alive and well

TVD AZTNoNoYesSkin tag (finger)NoNO Alive and well

TVD NVPNoNoYesASDNoNo Alive and well

TZV TDF RAL RTV DRVNoYesYesOesophageal atresiaNoOsophageal correction postnatally Alive and well

AZT TVD LPVNoNoYesVSDNoNo Alive and Well

AZT TVD SQV RTVNoNoYesTrisomy 21Yes, postnatallyNo Alive and well

LPV/r 3TC TDF AZTNoNoYesTrisomy 21 VSD and small ASDYes, postnatallyNo Alive and well

TVD
LPV/r
NoYesYesOmphaloceleNoNo Alive and well

TVD
LPV/r
NoYesYesSucking blisterNoNo Alive and well

NVP
TVD
NoYesYesNevus sebaceousNoNo Alive and well

46,xy,der(5)t(3;5)(p25.1p15.31).
46,xy,der(5)(5pter>5p15.31:3p25.1>3pter).
CDH: congenital diaphragmatic hernia; ASD: atrial septal defect; VSD: ventricular septal defect; MCDK: multicystic dysplastic kidney disease (Potter II); CBV: zidovudin/lamivudin; TDF: tenofovir; T20: enfuvirtide; NVP: nevirapin; AZT: zidovudin; 3TC: lamivudin; RAL: raltegravir; DRV: darunavir; SQV: saquinavir; RTV: ritonavir; TVD: tenofovir/emtricitabin; LPV/r: lopinavir/ritonavir.