Research Article
Prenatal Ultrasound Screening for Fetal Anomalies and Outcomes in High-Risk Pregnancies due to Maternal HIV Infection: A Retrospective Study
Table 4
Fetal and neonatal malformation/chromosomal anomalies.
| HAART | Diagnosis prenatally | Early scan (first trimester) | Detailed scan (second trimester) | Diagnosis postnatally | Invasive testing/Karyotype | Maternal coinfection | Duration of pregnancy in weeks + days | Outcome |
| CBV TDF T20 | CDH | No | Yes | CDH | No | HCV | | After operation alive and well |
| CBV NVP | VSD | Yes | Yes | VSD | No | HCV HBV | | MTCT |
| CBV NVP | Hydrocephalus, radial deviation of hands | No | Yes | confirmed | Yes (normal Karyotype) | No | | Died at 1 day |
| CBV NVP | Dandy Walker malformation | No | Yes | confirmed | Postnatally unbalanced translocation1 | No | | Died with 3 months |
| TVD AZT | MCDK Potter 2a | No | Yes | confirmed | Yes | No | | Alive and well |
| CBV NVP | Heart defect (ASD and dextrocardia) | No | Yes | confirmed | No | No | | Alive and well |
| TDF NVP 3TC | No | Yes | Yes | Skin tag (manubrium) | No | No | | Alive and well |
| TVD AZT | No | Yes | Yes | Skin tag (finger) | No | No | | Alive and well |
| TVD AZT | No | No | Yes | Skin tag (finger) | No | NO | | Alive and well |
| TVD NVP | No | No | Yes | ASD | No | No | | Alive and well |
| TZV TDF RAL RTV DRV | No | Yes | Yes | Oesophageal atresia | No | Osophageal correction postnatally | | Alive and well |
| AZT TVD LPV | No | No | Yes | VSD | No | No | | Alive and Well |
| AZT TVD SQV RTV | No | No | Yes | Trisomy 21 | Yes, postnatally | No | | Alive and well |
| LPV/r 3TC TDF AZT | No | No | Yes | Trisomy 21 VSD and small ASD | Yes, postnatally | No | | Alive and well |
| TVD LPV/r | No | Yes | Yes | Omphalocele | No | No | | Alive and well |
| TVD LPV/r | No | Yes | Yes | Sucking blister | No | No | | Alive and well |
| NVP TVD | No | Yes | Yes | Nevus sebaceous | No | No | | Alive and well |
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46,xy,der(5)t(3;5)(p25.1p15.31). 46,xy,der(5)(5pter>5p15.31:3p25.1>3pter). CDH: congenital diaphragmatic hernia; ASD: atrial septal defect; VSD: ventricular septal defect; MCDK: multicystic dysplastic kidney disease (Potter II); CBV: zidovudin/lamivudin; TDF: tenofovir; T20: enfuvirtide; NVP: nevirapin; AZT: zidovudin; 3TC: lamivudin; RAL: raltegravir; DRV: darunavir; SQV: saquinavir; RTV: ritonavir; TVD: tenofovir/emtricitabin; LPV/r: lopinavir/ritonavir.
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