The Effect of Cotrimoxazole Prophylactic Treatment on Malaria, Birth Outcomes, and Postpartum CD4 Count in HIV-Infected Women

Table 2

Frequency of outcomes of interest and effect estimates in CPT-exposed and CPT-unexposed pregnant women.

Outcome	CPT-unexposed women*	CPT-exposed women*	Total	Effect estimate^† (95% CI)
Malaria during pregnancy	7.2%; (33/457)	2.8%; (21/751)	4.5%; (54/1208)	HR: 0.35; (0.20, 0.60)
Low birth weight^‡	7.1%; (33/467)	7.6%; (58/762)	7.4%; (91/1229)	OR: 1.08; (0.70, 1.69)
Preterm birth	23.5%; (59/251)	23.6%; (88/373)	23.6%; (147/624)	RR: 1.00; (0.75, 1.34)

Totals for each outcome differ based on available data.
*Women were considered CPT-unexposed if they gave birth before June 13, 2006; women were considered CPT-exposed if they had their second prenatal visit after August 15, 2006.
^†Effect estimates are unadjusted as no confounders or effect measure modifiers met criteria for inclusion in final models.
^‡Data were missing for 7 infants.