Duration of Intrapartum Antibiotics for Group B Streptococcus on the Diagnosis of Clinical Neonatal Sepsis

Table 2

Effect of the duration of intrapartum antibiotic prophylaxis on the diagnosis of neonatal clinical sepsis.

Duration of IAP	Number of women	Diagnosis of neonatal clinical sepsis
<2 hours	385	6 (1.6)
2 to <4 hours	764	7 (0.9)
≥4 hours	3,633	15 (0.4)
	RR (95% CI)^#
	Crude	𝑃	Adjusted∗	P
<2 hour versus ≥4 hours	3.8 (1.5–9.7)	.01	3.5 (1.3–9.6)	.02
2 to <4 hours versus ≥4hours	2.2 (0.9–5.4)	.08	2.1 (0.8–5.5)	.12

IAP: intrapartum antibiotic prophylaxis; RR: relative risk; CI: 95th percentile confidence interval.
Data are 𝑛 (%) unless otherwise specified.
^#In multivariate analysis, odds ratios (OR) were assumed to approximate relative risks (RR) because clinical sepsis was rare in this population [16].
∗Adjusted by multivariate logistic regression for maternal age and the duration of rupture of membranes.