|
Sr.
number | Author (year) | Objective | Region | Setting | Sample | Period | Outcomes | Results |
|
| 1 | Mathur et al.
(2013) [37] | To assess the clinical profile, factors determining the response, prognosis of the disease, and outcome in H1N1 positive patients during 2009-2010 H1N1 pandemic | Jodhpur
(West India) | Hospital-based,
ICU/isolation patients | Overall population: 221
Pregnant women: 37 | 2009-2010 | Clinical and epidemiological characteristics | Prevalence of Influenza virus:
(i) Influenza A (pH1N1): 37 (23.4%)
Length of pregnancy at presentation:
(i) First trimester: 4 (11%)
(ii) Second trimester: 18 (49%)
(iii) Third trimester: 15 (40%)
Maternal mortality:
(i) 26 (70%) pregnant women died
(ii) Mortality in third trimester: 80%
Treatment:
(i) All patients received Oseltamivir, Zanamivir, oxygen and ventilatory therapy, intravenous antibiotics and fluids, low dose steroids, and symptomatic therapy according to WHO guidelines |
|
| 2 | Mehta et al.
(2013) [38] | To observe clinical profile of admitted patients with confirmed H1N1 swine flu infection and risk factors associated with the need of mechanical ventilation and/or death | Kochi, Kerala
(South India) | Hospital-based
inpatient | Overall population: 115
Pregnant women: 6 | August 2009 to December 2011
(28 months) | Clinical and epidemiological characteristic
Risk factors associated
with mechanical ventilation/death | Influenza virus prevalence:
(i) Influenza A (H1N1): 5.2%
Maternal mortality: 2 women (33%)
Loss of fetus: 2 women (33%)
Preterm delivery: 2 women (33%)
Treatment:
All patients received Oseltamivir 75 mg twice daily for 5–10 days as per CDC guidelines |
|
| 3 | Ramakrishna et al.
(2012) [36] | To detail the profile and outcomes of patients admitted to the intensive care unit (ICU) with pandemic Influenza A (H1N1) 2009 virus [P(H1N1)2009v] infection | Bangalore, Vellore, Manipal
(South India) | Hospital-based,
ICU patients | Overall population: 1902
Pregnant women: 19 | September 2009–December 2009
(4 months) | (i) Hospital mortality
(ii) Need for any duration of ventilation, tracheostomy, and skeletal muscle relaxants
(iii) Need for renal replacement therapy
(iv) Duration of ICU
(v) Hospital stay | Onset of infection:
(i) Antepartum: 14 women
(ii) Postpartum: 5 women
Maternal mortality:
(i) 10 pregnant/postpartum women (52.6%) died
(ii) Other outcomes were not described separately for pregnant women
Treatment:
All patients received Oseltamivir; no separate mention of timing of initiation of Oseltamivir in pregnant women |
|
| 4 | Gunasekaran (2012) [33] | To determine the cumulative prevalence of H1N1 2009 influenza among pregnant and postpartum women in Tamil Nadu | Chennai
(South India) | Hospital-based,
inpatient and outpatient | Overall population: 7638
Pregnant women: 126 | September 2009–May 2011
(21 months) | Clinical and epidemiological characteristics | Prevalence of influenza virus:
(i) Influenza (pH1N1): 27 women (21.4%)
(ii) Influenza A/H3: 12 women (9.5%)
(iii) Influenza B: 2 women (1.6%)
Onset of infection:
(i) Antepartum: 12 women
(ii) Postpartum: 15 women
ICU admission and complication:
(i) Admitted in ICU and treated for severe outcomes: 3 (11.1%)
(ii) Admitted in obstetric ward and treated for moderate outcomes: 5 (18.5%) women
Maternal mortality:
(i) One woman died during postpartum period
Treatment:
Oseltamivir was initiated in patients considering their high-risk status |
|
| 5 | Pramanick et al.
(2011) [34] | To assess the clinical profile of pregnant/puerperal women infected with pandemic H1N1 influenza A and to evaluate their outcome | Vellore
(South India) | Hospital-based | Overall population: 566
Pregnant women: 20 | August 2009–January 2010
(6 months) | Primary outcome
(i) Maternal mortality
Secondary outcomes
(ii) Need for ICU admission
(iii) Need for mechanical ventilation
(iv) Renal failure | (i) Out of 79 pregnant women, 20 (29%) women presenting with ILI/SARI were pregnant
Onset of infection:
(i) Antepartum: 16 women (80%)
(ii) Postpartum: 4 women (20%)
Length of pregnancy at presentation:
(i) Second trimester: 4 women (20%)
(ii) Third trimester: 11 women (55%)
(iii) 1 woman had molar pregnancy at 18 weeks of pregnancy
ICU admission:
(i) Required by 8 pregnant/postpartum (40%)
Maternal mortality: 5 women (25%) died
Fetal mortality: 1
Complications:
(i) Renal failure: 4 women (20%)
(ii) Mechanical ventilation: 7 women (35%)
(iii) Seizures: 1 woman (5%)
Treatment:
Oseltamivir received by 18 women (90%); no mention of timing of initiation of Oseltamivir |
|
| 6 | Puvanalingam et al. (2011) [35] | To study clinical profile of H1N1 influenza cases and to study the impact of H1N1 infection on pregnancy outcome | Chennai
(South India) | Hospital-based
inpatient and outpatient | Overall population: 442
Pregnant women: 12 | August 2009–January 2010
(6 months) | Clinical characteristics
and outcome of pregnant women | Length of pregnancy at presentation:
(i) First trimester: 2 (16.7%) women
(ii) Second trimester: none
(iii) Third trimester: 10 (83.3%) women
Maternal mortality:
3 women (25%) died
Complication:
(i) 9 women (75%) presented with pneumonia
Fetal death:
(i) 2 women (16.7%) had spontaneous abortion following intrauterine death in the third trimester
Treatment: not mentioned |
|
| 7 | Chudasama et al.
(2010) [32] | To investigated the clinicoepidemiological characteristics of patients who were hospitalized with 2009 pandemic H1N1 influenza virus infection and seasonal influenza in the Saurashtra region of India | Rajkot
(West India) | Hospital-based
inpatient | Overall population: 773
Pregnant women: 15 | September 2009–February 2010
(6 months) | Clinical and epidemiological characteristics | Length of pregnancy at presentation:
(i) All women presented in either 2nd or 3rd trimester
ICU admission:
(i) 11 women (73.3%) required intensive care
Treatment:
All patients received Oseltamivir, no separate mention of number of pregnant women that received the drug within 2 days of illness onset |
|
| 8 | Sharma et al.
(2010) [39] | To describe the mortality data of severe influenza cases admitted in a tertiary care center in New Delhi | New Delhi
(North India) | Hospital-based
inpatient | Total: 8 women
Pregnant women: 2 | September 2009 to January 2010
(5 months) | Mortality | Out of 8 deaths due to influenza A (pH1N1), 2 women were pregnant
Length of pregnancy at presentation:
(i) First trimester: one woman
(ii) Postpartum period: one woman, child delivered by caesarean section |
|
