Review Article
Candida Chorioamnionitis Leads to Preterm Birth and Adverse Fetal-Neonatal Outcome
Table 1
Clinical features of nine cases of Candida chorioamnionitis in our hospital.
| Case | Age (y) | GA at delivery | Species | Positive culture | Predisposing conditions | Clinical signs | BW (g) | CCC | Neonatal outcome |
| 1 | 31 | 21 w 6 d | Candida albicans | Amniotic fluid | IVF | Preterm labor and afebrile WBC: 16,500/mm3 CRP: 0.51 mg/dL | 490 | No | Artificial abortion | 2 | 31 | 22 w 6 d | C. glabrata | Amniotic fluid | IVF | Preterm labor and afebrile WBC: 11,600/mm3 CRP: 1.68 mg/dL | 594 | Yes | Death on day 59 | 3 | 28 | 23 w 0 d | C. famata | Amniotic fluid | Smoking | Preterm labor and afebrile WBC: 16,400/mm3 CRP: 0.68 mg/dL | 498 | No | Hydrocephalus after IVH | 4 | 35 | 23 w 3 d | C. albicans | Amniotic fluid | IVF Gestational diabetes | Preterm labor and afebrile WBC: 11,700/mm3 CRP: 3.71 mg/dL | 580 | Yes | Neonatal death | 5 | 28 | 23 w 4 d | C. albicans | Amniotic fluid | Pregestational diabetes | Preterm labor and afebrile WBC: 12,600/mm3 CRP: 3.8 mg/dL | 536 | No | Brain atrophy and CLD | 6 | 33 | 25 w 2 d | C. albicans | Amniotic fluid | None | Preterm labor and afebrile WBC: 15,400/mm3 CRP: 7.51 mg/dL | 786 | No | PDA ligation | 7 | 26 | 26 w 6 d | C. albicans | Amniotic fluid | None | Preterm labor and afebrile WBC: 9,800/mm3 CRP: 3.05 mg/dL | 924 | Yes | CLD | 8 | 36 | 28 w 2 d | C. albicans | Umbilical blood | Di-Di twins | Preterm labor and afebrile WBC: 9,500/mm3 CRP: 3.34 mg/dL | 1,290/1,168 | No | Normal Only one twin had the infection | 9 | 38 | 33 w 3 d | C. glabrata | Amniotic fluid | pPROM | Afebrile, WBC: 10,200/mm3 CRP: 2.68 mg/dL | 1,912 | No | Normal |
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GA, gestational age; BW, birth weight; CCC, congenital cutaneous candidiasis; IVF, in vitro fertilization; Di-Di twin, dichorionic diamniotic twin; WBC, white blood cell; CRP, C-reactive protein; IVH, intraventricular hemorrhage; CLD, chronic lung disease; PDA, patent ductus arteriosus; pPROM, preterm premature rupture of membranes.
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